多功能多靶点药物是21世纪药理学的基础

P. Vasilyev, V. Kosolapov, A. Spasov, L. Yanalieva
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引用次数: 2

摘要

由于所有疾病都开始被认为是多因子的,21世纪药理学的主要方向是设计多靶点配体。作者在心脏九种离子通道对三种抗心律失常药物的亲和谱分析领域的研究,以及对糖基化终产物受体的多功能多靶点抑制剂的初步研究结果,证实了这种方法的相关性。
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Polyfunctional Multitarget Drugsas a Basis of Pharmacologyof the 21st Century
Due to the fact that all diseases began to be considered as multifactorial, the main direction of pharmacology in the 21st century is the design of multitarget ligands. The relevance of this approach is confirmed by the authors’ research in the field of analysis of the spectrum of affinity for nine ion channels of the heart for three antiarrhythmic drugs, as well as the results of initiatory research into the search for fundamentally new multifunctional multitarget inhibitors of glycation end-product receptors.
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