外泌体的生物学功能及其在药物研究中的应用

Mengmeng Fu, Jiapeng Li, Tungalag Battulga, Xiaoxue Li, Ming Xu
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外泌体的生物学功能及其在药物研究中的应用综述傅梦梦1,李佳鹏1,Tungalag Battulga 2,李晓雪3,*,徐明1,*1中国药科大学基础医学与临床药学院临床药学系,南京同家弄24号210009 .2蒙古医科大学药学院,蒙古乌兰巴托24210 .3蒙古医科大学中大医院心内科东南大学,江苏南京210009*通信:lxx84112@163.com(李晓雪);mingxu@cpu.edu.cn;摘要:外泌体作为细胞间通讯的重要物质,近年来受到越来越多的关注。在大量的新研究中,它们与药物的独特相互作用更加引人注目。外泌体作为细胞外囊泡发挥生物学功能或作为药物载体递送治疗剂在疾病治疗中发挥重要作用。我们总结了外泌体与药物在疾病进展和治疗中的关系。了解外泌体如何与药物相互作用并发挥其抗炎和促血管生成作用,以及以不同方式抑制脂质过氧化的结果,对疾病治疗至关重要。
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Biological Functions and Applications of Exosomes in Drug Research
Review Biological Functions and Applications of Exosomes in Drug Research Mengmeng Fu 1, Jiapeng Li 1, Tungalag Battulga 2, Xiaoxue Li 3, *, and Ming Xu 1, * 1 Department of Clinical Pharmacy, School of Preclinical Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tong jia Lane, Nanjing 210009, China. 2 School of Pharmacy, Mongolian National University of Medical Sciences, Ulaanbaatar-24210, Mongolia. 3 Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China. * Correspondence: lxx84112@163.com(Xiaoxue Li); mingxu@cpu.edu.cn; Tel.: 025-86185653(Ming Xu)     Received: 9 October 2022 Accepted: 12 November 2022 Published: 11 January 2023   Abstract: Exosomes have received increasing attention in recent years as an important substance for intercellular communication. Among the plethora of new research is their unique interaction with drugs is even more striking. Exosomes play essential roles in disease treatment either as extracellular vesicles to exert biological functions or as drug carriers to deliver therapeutic agents. We summarized the relationship between exosomes and drugs in the disease progression and treatment. Understanding how exosomes interact with drugs and exert their anti-inflammatory and pro-angiogenic effects, alongside a lipid peroxidation inhibitory result in different manners is essential for disease treatment.
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