Minyu CHEN , Ni ZHENG , Wenqi LIU , Dingrong WAN , Rumei LU , Xinzhou YANG
{"title":"Seladoeneolignan A，一种新木聚糖属植物。","authors":"Minyu CHEN , Ni ZHENG , Wenqi LIU , Dingrong WAN , Rumei LU , Xinzhou YANG","doi":"10.1016/S2707-3688(23)00042-0","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To study the chemical compositions from <em>Selaginella doederleinii</em> Hieron.</p></div><div><h3>Methods</h3><p>The petroleum ether and ethyl acetate fractions of 80% ethanol extract of <em>S. doederleinii</em> were separated and purified by macroporous resin, silica gel, Sephadex LH-20 and semi-preparative HPLC, and then the structures of obtained compounds were identified by physicochemical properties and spectroscopical data.</p></div><div><h3>Results</h3><p>A total of 7 compounds were isolated and identified as seladoeneolignan A <strong>(1),</strong> ethoxy-ferulate <strong>(2),</strong> 11-dien-19-oic acid <strong>(3),</strong> aurantiamide <strong>(4),</strong> 9,16-dioxo-10,12,14-octadeca-trienoic acid <strong>(5),</strong> amentoflavone <strong>(6),</strong> and 7,4’-di-0-methylrobustaflavone <strong>(7).</strong></p></div><div><h3>Conclusion</h3><p>Compound <strong>1</strong> was a new neolignan obtaind from <em>S. doederleinii</em> for the first time. Compounds <strong>1, 6</strong> and <strong>7</strong> were screened for antitumor activity in vitro, and the testing results showed that 3 compounds had low inhibitory activity on Hep-2 and Eca-109 tumor cells.</p></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"3 3","pages":"Pages 224-229"},"PeriodicalIF":0.0000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2707368823000420/pdfft?md5=59914ff8786691b33cd1ef64dc7b7e84&pid=1-s2.0-S2707368823000420-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Seladoeneolignan A, a new neolignan from Selaginella doederleinii Hieron.\",\"authors\":\"Minyu CHEN , Ni ZHENG , Wenqi LIU , Dingrong WAN , Rumei LU , Xinzhou YANG\",\"doi\":\"10.1016/S2707-3688(23)00042-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To study the chemical compositions from <em>Selaginella doederleinii</em> Hieron.</p></div><div><h3>Methods</h3><p>The petroleum ether and ethyl acetate fractions of 80% ethanol extract of <em>S. doederleinii</em> were separated and purified by macroporous resin, silica gel, Sephadex LH-20 and semi-preparative HPLC, and then the structures of obtained compounds were identified by physicochemical properties and spectroscopical data.</p></div><div><h3>Results</h3><p>A total of 7 compounds were isolated and identified as seladoeneolignan A <strong>(1),</strong> ethoxy-ferulate <strong>(2),</strong> 11-dien-19-oic acid <strong>(3),</strong> aurantiamide <strong>(4),</strong> 9,16-dioxo-10,12,14-octadeca-trienoic acid <strong>(5),</strong> amentoflavone <strong>(6),</strong> and 7,4’-di-0-methylrobustaflavone <strong>(7).</strong></p></div><div><h3>Conclusion</h3><p>Compound <strong>1</strong> was a new neolignan obtaind from <em>S. doederleinii</em> for the first time. Compounds <strong>1, 6</strong> and <strong>7</strong> were screened for antitumor activity in vitro, and the testing results showed that 3 compounds had low inhibitory activity on Hep-2 and Eca-109 tumor cells.</p></div>\",\"PeriodicalId\":100787,\"journal\":{\"name\":\"Journal of Holistic Integrative Pharmacy\",\"volume\":\"3 3\",\"pages\":\"Pages 224-229\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2707368823000420/pdfft?md5=59914ff8786691b33cd1ef64dc7b7e84&pid=1-s2.0-S2707368823000420-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Holistic Integrative Pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2707368823000420\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Holistic Integrative Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2707368823000420","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Seladoeneolignan A, a new neolignan from Selaginella doederleinii Hieron.
Objective
To study the chemical compositions from Selaginella doederleinii Hieron.
Methods
The petroleum ether and ethyl acetate fractions of 80% ethanol extract of S. doederleinii were separated and purified by macroporous resin, silica gel, Sephadex LH-20 and semi-preparative HPLC, and then the structures of obtained compounds were identified by physicochemical properties and spectroscopical data.
Results
A total of 7 compounds were isolated and identified as seladoeneolignan A (1), ethoxy-ferulate (2), 11-dien-19-oic acid (3), aurantiamide (4), 9,16-dioxo-10,12,14-octadeca-trienoic acid (5), amentoflavone (6), and 7,4’-di-0-methylrobustaflavone (7).
Conclusion
Compound 1 was a new neolignan obtaind from S. doederleinii for the first time. Compounds 1, 6 and 7 were screened for antitumor activity in vitro, and the testing results showed that 3 compounds had low inhibitory activity on Hep-2 and Eca-109 tumor cells.
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