利用PSA、PXRD、TGA/DTG和DSC分析技术表征生物场能量处理氟他胺的理化和热性能

A. Branton, M. Trivedi, Dahryn Trivedi, G. Nayak, S. Jana
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摘要

氟他胺是一种抗雄激素药物,通过与雄激素受体结合来阻断睾酮的作用。本研究旨在确定Trivedi效应®-意识能量治疗对氟他胺的物理化学和热性能的影响。试验样品分为对照和处理样品两部分。对照部分被称为未经处理的样本,而被治疗的部分则由著名的生物场能量治疗师Alice Branton远程接受生物场能量治疗。研究表明,经处理后的颗粒粒径值分别显著提高了15.82%(d10)、16.36%(d50)、1.05%(d90)和5.10% {D (4,3)};因此,处理后的样品比表面积比对照样品显著降低了14.56%。处理后氟他胺的PXRD峰强度和晶粒尺寸发生了显著变化,分别为7.02% ~ 29.41%和-9.17% ~ 17.86%,平均晶粒尺寸较对照增加了2.84%。残重显著降低64.16%;但处理后样品的最大热降解温度较对照样品提高了10.16%。处理后样品的潜热比对照样品降低了9.37%。结果表明,与未处理样品相比,处理样品的结晶度,粒度和热稳定性发生了显着变化。因此,与未经处理的样品相比,经生物场能量处理的氟他胺可能改善流动性和相容性,这可能有助于设计更好的药物配方,以提高其抗各种疾病的性能。
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Characterization of the Physicochemical and Thermal properties of the Biofield Energy Treated Flutamide Using PSA, PXRD, TGA/DTG, and DSC Analytical Techniques
Flutamide is an antiandrogen drug that blocks the action of testosterone by binding to the androgen receptor. This study was designed to determine the impact of the Trivedi Effect®-Energy of Consciousness Healing Treatment on the physicochemical and thermal properties of flutamide. The test sample was divided into two parts, i.e., control and treated sample. The control part was known as untreated sample, while the treated part remotely received the Biofield Energy Healing Treatment by a renowned Biofield Energy Healer, Alice Branton. The study showed that the particle size values were significantly increased by 15.82%(d10), 16.36%(d50), 1.05%(d90), and 5.10% {D (4, 3)}; thus, the specific surface area was significantly decreased by 14.56% in the treated sample compared with the control sample. The PXRD peak intensities and crystallite sizes were significantly altered ranging from 7.02% to 29.41% and -9.17% to 17.86%, along with 2.84% increase in the average crystallite size in the treated flutamide compared to the control sample. The residue weight was significantly decreased by 64.16%; however, the maximum thermal degradation temperature was increased by 10.16% in the treated sample compared to the control sample. The latent heat of the treated sample reduced by 9.37% compared with the control sample. The results revealed the significant alteration in the crystallinity, particle size and thermal stability of the treated sample as compared to the untreated sample. Thus, the Biofield Energy Treated flutamide might improve the flowability, and compatibility compared with the untreated sample, that may help in designing a better pharmaceutical formulation in terms of its performance against various diseases.
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