{"title":"蛋白质在细胞核中的聚集:结构、功能和拓扑结构","authors":"A. Mikecz","doi":"10.2174/1874196700902020193","DOIUrl":null,"url":null,"abstract":"The nucleus represents a cellular control unit that regulates all events concerning the storage and processing of DNA and RNA. It is organized by highly crowded, dynamic assemblies of proteins and nucleic acids in molecular machines, ribonucleoprotein complexes, clusters of ongoing nuclear processes, nuclear bodies, and chromatin. This review discusses the occurrence of nuclear protein aggregation with special emphasis on the functional architecture of the nucleus, and quality control by the ubiquitin-proteasome system.","PeriodicalId":22949,"journal":{"name":"The Open Biology Journal","volume":"29 1","pages":"193-199"},"PeriodicalIF":0.0000,"publicationDate":"2010-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Protein Aggregation in the Cell Nucleus: Structure, Function and Topology~!2009-04-10~!2009-06-05~!2010-01-02~!\",\"authors\":\"A. Mikecz\",\"doi\":\"10.2174/1874196700902020193\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The nucleus represents a cellular control unit that regulates all events concerning the storage and processing of DNA and RNA. It is organized by highly crowded, dynamic assemblies of proteins and nucleic acids in molecular machines, ribonucleoprotein complexes, clusters of ongoing nuclear processes, nuclear bodies, and chromatin. This review discusses the occurrence of nuclear protein aggregation with special emphasis on the functional architecture of the nucleus, and quality control by the ubiquitin-proteasome system.\",\"PeriodicalId\":22949,\"journal\":{\"name\":\"The Open Biology Journal\",\"volume\":\"29 1\",\"pages\":\"193-199\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-01-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Open Biology Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874196700902020193\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Biology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874196700902020193","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Protein Aggregation in the Cell Nucleus: Structure, Function and Topology~!2009-04-10~!2009-06-05~!2010-01-02~!
The nucleus represents a cellular control unit that regulates all events concerning the storage and processing of DNA and RNA. It is organized by highly crowded, dynamic assemblies of proteins and nucleic acids in molecular machines, ribonucleoprotein complexes, clusters of ongoing nuclear processes, nuclear bodies, and chromatin. This review discusses the occurrence of nuclear protein aggregation with special emphasis on the functional architecture of the nucleus, and quality control by the ubiquitin-proteasome system.
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