传统加热与微波辐照环缩合法制备三嗪联吡唑杂环化合物及其抗结核和抗菌活性评价

IF 0.5 4区 化学 Q3 Pharmacology, Toxicology and Pharmaceutics Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2020-11-19 DOI:10.56042/ijcb.v59i11.30111
P. P. Deohate, Roshani S. Mulani
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引用次数: 0

摘要

的合成(4-benzylideneamino-6-methyl -[1、3、5]-triazin-2-yl)——(5-methyl-2-substituted苯基/ H -pyrazol-3-yl) -胺和(4-benzylideneamino-6-methyl -[1、3、5]-triazin-2-yl)——(5-methyl-2-substituted / isonicotinoyl / cinnamoyl-pyrazol-3-yl)苯甲酰胺通过常规加热和微波会发光的cyclocondensation cyclisation取得的N - (4-benzylideneamino-6-methyl -[1、3、5]-triazin-2-yl) 3-oxo butyramide取代肼和酸酰肼类。以2,4-二氨基-6-甲基-[1,3,5]-三嗪与苯甲醛反应,再与乙酰乙酸乙酯缩合,合成了所需的丁酰胺。除了化学转化和元素分析外,还对合成的化合物进行了IR、1h NMR和质谱分析。对标题化合物的抗结核和抗菌潜力进行了评价,以确定其对某些选定微生物的结构活性关系。
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Synthesis of triazine linked pyrazole heterocyclics by conventional heating and microwave irradiative cyclocondensation and evaluation of antitubercular and antimicrobial potential
The synthesis of (4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-(5-methyl-2-substituted phenyl/ H -pyrazol-3-yl)- amines and (4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-(5-methyl-2-substituted benzoyl/isonicotinoyl/cinnamoyl-pyrazol-3-yl)-amines by conventional heating and microwave irradiative cyclocondensation have been achieved by the cyclisation of N-(4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-3-oxo butyramide with substituted hydrazines and acid hydrazides. The required butyramide has been synthesized by the reaction of 2,4-diamino-6-methyl-[1,3,5]-triazine with benzaldehyde followed by the condensation with ethyl acetoacetate. Structural elucidation of synthesized compounds has been performed by IR, 1 H NMR and mass spectral studies besides chemical transformation and elemental analysis. The title compounds have been evaluated for their antitubercular and antimicrobial potential against some selected microorganisms to establish the structure activity relationship.
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来源期刊
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0.00%
发文量
1
审稿时长
4-8 weeks
期刊介绍: Indian Journal of Chemistry (Section B) is a leading monthly journal in Organic and Medicinal Chemistry started publishing from 1976. It publishes papers on organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry. Apart from full length papers, notes and communications, the journal publishes short reviews on frontline areas under the column " advances in Contemporary Research".
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