离子迁移率光谱法在阴道感染诊断中的最新应用

Z. Karpas, G. Cohen, E. Atweh, G. Barnard, M. Golan
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引用次数: 7

摘要

阴道感染(阴道病)影响全球15%以上的育龄女性人口。然而,阴道病的诊断和区分三种常见类型:细菌性阴道病(BV),外阴阴道念珠菌病(VVC)和滴虫病是具有挑战性的。生物胺、三甲胺(TMA)、腐胺和尸胺水平升高已在阴道病妇女的阴道分泌物中发现。离子迁移率光谱法(IMS)特别适用于测量胺,甚至在复杂的生物基质中,由于它们的高质子亲和力,并已被证明适用于阴道感染的诊断。最近的发展,提高了准确性的技术诊断细菌性肠胃炎和简化了样本的介绍在这里。
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Recent Applications of Ion Mobility Spectrometry in Diagnosis of Vaginal Infections
Vaginal infections (vaginosis) globally affect more than 15% of the female population of reproductive age. However, diagnosis of vaginosis and differentiating between the three common types: bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and trichomoniasis are challenging. Elevated levels of the biogenic amines, trimethylamine (TMA), putrescine, and cadaverine have been found in vaginal discharge fluid of women with vaginosis. Ion mobility spectrometry (IMS) is particularly suitable for measurement of amines even in complex biological matrices due to their high proton affinity and has been shown to be suitable for the diagnosis of vaginal infections. Recent developments that have increased the accuracy of the technique for diagnosis of BV and simplified sample introduction are described here.
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