(Tn抗原)。

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme Pub Date : 2020-02-02 DOI:10.32388/nxgt9h

H. Nakada

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引用次数: 1

摘要

一种蛋白质抗原，由单糖n -乙酰半乳糖胺(GalNAc)组成，通过o链糖基化与丝氨酸或苏氨酸结合所有血细胞谱系中Tn抗原的异常表达与一种称为Tn综合征的罕见血液学疾病有关。这种单糖修饰的表达增加也与某些癌症有关，这种抗原正在被研究作为这些相关恶性肿瘤的生物标志物或治疗靶点。

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[Tn antigen].

A protein antigen that is comprised of the monosaccharide N-acetylgalactosamine (GalNAc) bound to serine or threonine by O-linked glycosylation. Aberrant expression of Tn antigen by all blood cell lineages is associated with a rare hematological disorder called Tn-syndrome. Increased expression of this monosaccharide modification is also associated with some cancers and this antigen is being investigated for use as either a biomarker or therapeutic target for these associated malignancies.

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