早产新生儿胆汁淤积和先天性神经母细胞瘤1例报告

IF 0.1 Q4 OBSTETRICS & GYNECOLOGY Case Reports in Perinatal Medicine Pub Date : 2022-09-02 DOI:10.1515/crpm-2021-0089

S. Puvabanditsin, Melissa Guillermo, Yi-Chou Cheng, Olga Sudol, R. Mehta

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摘要

摘要目的神经母细胞瘤(Neuroblastoma, NB)是围产期最常见的肿瘤之一。新生儿新生儿NB的临床特征与老年人群不同。通常，先天性神经母细胞瘤是在产前偶然发现的。新生儿NBs的临床表现变化很大。一例早产24天、孕32周的男婴出现胆汁淤积，诊断为MS期神经母细胞瘤。未发现NB主站点。结论:据我们所知，这是第一例转移性NB (MS期)在早产新生儿中表现为胆汁症，但没有任何可识别的肾上腺或肾上腺外原发灶。

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Cholestasis and congenital neuroblastoma in a preterm neonate: a case report

Abstract Objectives Neuroblastoma (NB) is one of the most common tumor during perinatal period. The clinical features of NB occurring in fetuses and neonates differ from that in the older age groups. Frequently, Congenital neuroblastomas are incidentally detected prenatally. Clinical presentations of NBs in neonates are highy variable. Case presentation A 24-day old preterm 32 weeks’ gestation male neonate developed cholestasis that lead to the diagnosis of stage MS neuroblastoma. There was no NB primary site identified. Conclusions To the best of our knowledge, this is the first case report of metastatic NB (Stage MS) in a preterm neonate presenting with cholestsis but without any identifiable adrenal or extra-adrenal primary.

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Case Reports in Perinatal Medicine OBSTETRICS & GYNECOLOGY-

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期刊介绍： Case Reports in Perinatal Medicine is a double-blind peer-reviewed journal. The objective of the new journal is very similar to that of JPM. In addition to evidence-based studies, practitioners in clinical practice esteem especially exemplary reports of cases that reveal specific manifestations of diseases, its progress or its treatment. We consider case reports and series to be brief reports describing an isolated clinical case or a small number of cases. They may describe new or uncommon diagnoses, unusual outcomes or prognosis, new or infrequently used therapies and side effects of therapy not usually discovered in clinical trials. They represent the basic concept of experiences for studies on representative groups for further evidence-based research. The potential roles of case reports and case series are: Recognition and description of new diseases Detection of drug side effects (adverse or beneficial) Study of mechanisms of disease Medical education and audit Recognition of rare manifestations of disease.