In-Silico and In-Vitro Studies of Synthesized 3-(3,4-Dimethoxyphenyl)-1-(2-hydroxy-5-methylphenyl)- prop-2-en-one and Derivatives #

In the present study, research is devoted to the synthesis and characterization of 3,4-Dimethoxy-2’-Hydroxy-5’-methyl chalcone and its analogues i.e. flavone, flavanone, aurone, flavanol, chalconeimine, isooxazoline, and acetoxy chalcone. These compounds were evaluated for their pharmacodynamics and pharmacokinetics features by in-silico ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) screenings. They were also exploited for in-vitro antimicrobial screenings. #Some part of this paper was presented at ECSOC-13, The 13 International Electronic Conference on Synthetic Organic Chemistry, 1-30 Nov, 2009.