除了疾病分类学吗?分子肿瘤板,单一性,以及诊断和治疗的合并

IF 1.3 4区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY New Genetics and Society Pub Date : 2020-12-08 DOI:10.1080/14636778.2020.1853512
A. Cambrosio, Jonah Campbell, P. Bourret
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引用次数: 10

摘要

本文参与了一些最近的尝试,以绘制临床工作的重新配置,作为精确肿瘤学部署的一部分。我们重点关注平台,特别是分子肿瘤委员会,它们作为实施创新实验干预的可能性条件,并且是超越传统诊断限制的数据“生态系统”的出现的一部分,旨在增加患者获得与其基因组图谱相匹配的药物。mtb是这一单一过程的关键组成部分,它们的活动是将个体患者的诊断与诊断类别的修订联系起来的循环机制的核心。这些分类不再“仅仅”是诊断,而是作为治疗的预测性指南。
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Beyond nosology? Molecular tumor boards, singularization, and the conflation of diagnosis and therapy
This article partakes in a number of recent attempts to map the reconfiguration of clinical work as part of the deployment of precision oncology. We focus on the platforms, in particular Molecular Tumor Boards, that act as a condition of possibility for implementing innovative experimental interventions, and which are part of the emergence, beyond the traditional confines of diagnosis, of a data “ecosystem” geared towards increasing patient access to drugs matched to their genomic profile. MTBs are a key component of this singularization process, and their activities are central to the looping mechanisms that connect the diagnosis of individual patients to the revision of diagnostic categories. These categories are no longer “merely” diagnostic but operate as predictive guides to therapy.
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来源期刊
New Genetics and Society
New Genetics and Society 生物-生物工程与应用微生物
CiteScore
4.30
自引率
16.70%
发文量
19
审稿时长
>12 weeks
期刊介绍: New Genetics and Society: Critical Studies of Contemporary Biosciences is a world-leading journal which: -Provides a focus for interdisciplinary and multi-disciplinary, leading-edge social science research on the new genetics and related biosciences; -Publishes theoretical and empirical contributions reflecting its multi-faceted development; -Provides an international platform for critical reflection and debate; -Is an invaluable research resource for the many related professions, including health, medicine and the law, wishing to keep abreast of fast changing developments in contemporary biosciences. New Genetics and Society publishes papers on the social aspects of the new genetics (widely defined), including gene editing, genomics, proteomics, epigenetics and systems biology; and the rapidly developing biosciences such as biomedical and reproductive therapies and technologies, xenotransplantation, stem cell research and neuroscience. Our focus is on developing a better understanding of the social, legal, ethical and policy aspects, including their local and global management and organisation.
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