几种非芳香族酯类化合物的合成及其体外抗镰刀病活性研究

American Chemical Science Journal Pub Date : 2016-01-10 DOI:10.9734/acsj/2016/22734

D. Tshilanda, K. Ngbolua, D. Tshibangu, A. Malumba, P. Mpiana

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引用次数: 4

摘要

有机酸及其衍生物，如硬脂酸丁酯，最近显示出抗镰刀病活性。合成了几种无芳香族酯，并用Emmel法测定了它们的抗镰刀病活性。在测试的21种酯中，只有3种没有抗镰状细胞活性。棕榈酸丁酯、棕榈酸丙酯、硬脂酸丁酯、硬脂酸丙酯和壬烷酸甲酯表现出良好的抗镰刀病活性，正规化率均高于70%。

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Synthesis and in vitro Antisickling Activity of Some Non-aromatic Esters

Organic acids and their derivatives like butyl stearate have recently shown antisickling activity. Some none aromatic esters were synthetized and tested for their antisickling activity using Emmel test. On 21 esters tested only three showed no antisickling activity. Butyl palmitate, propyl palmitate, butyl stearate, propyl stearate and methyl nonadecanoate showed interesting antisickling activity with a normalization rate higher than 70%.

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American Chemical Science Journal

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