1,4- dhp衍生物谷胱甘肽对DNA影响的体外实验研究

Q4 Multidisciplinary Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. Pub Date : 2023-02-01 DOI:10.2478/prolas-2023-0006

E. Leonova, Kristīne Dišlere, E. Rostoka, L. Baumane, E. Bisenieks, G. Duburs, N. Sjakste

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引用次数: 1

摘要

摘要本研究的目的是测试1,4- dhp组的代表-谷胱甘肽保护DNA免受损伤的能力。该化合物增加了芬顿反应中产生的羟基自由基的浓度，它不能清除过氧亚硝酸盐，也不能保护质粒DNA免受芬顿反应产物的损伤。另一方面，该化合物保护HeLa细胞免受过氧化物铁矿和b淋巴细胞的损伤，在转染来自HIV病毒的Tat蛋白诱导的氧化应激条件下免受DNA损伤。据推测，谷胱甘肽可以激活DNA修复系统。

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Study of Impact of a 1,4-DHP Derivative Glutapyrone on DNA Using In Vitro Tests

Abstract The goal of the study was to test the ability of a representative of the 1,4-DHP group — glutapyrone to protect DNA against damage. The compound increased the concentration of the hydroxyl radicals produced in the Fenton reaction, it did not scavenge peroxynitrite and did not protect plasmid DNA against damage by products of the Fenton reaction. On the other hand, the compound protected HeLa cells against damage by peroxinitrite and B-lymphocytes against DNA damage in the conditions of oxidative stress induced by transfection of the Tat protein derived from the HIV virus. It is supposed that glutapyrone mobilises DNA repair systems.

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