Adenosine Kinase Expression Modulates Expression of Myelin Proteolipid Protein

Adenosine is known to regulate myelination in vitro. Here we tested the hypothesis that adenosine, regulated by adenosine kinase (ADK), might regulate myelin-specific protein expression and myelination in vivo. We demonstrate that transgenic overexpression of ADK, which reduces adenosine in mouse brain, results in increased levels of myelin prote- olipid protein.