Q4 Medicine Duzce Medical Journal Pub Date : 2022-08-31 DOI:10.47493/abantmedj.1120849
Oruç Yunusoğlu, Çagla Köse, Sibel Özyazgan, Andleeb Shahzadi̇, Bülent Demir, Burak Önal, A. Akkan
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引用次数: 1

摘要

目的:阿片类药物依赖是一种以复发和缓解为特征的慢性复杂疾病。长期服用吗啡会引起身体和心理依赖的症状。本研究旨在探讨安非他酮、伐尼克兰等抗成瘾药物对吗啡依赖和纳洛酮沉淀戒断综合征大鼠模型的影响。材料与方法:为评估吗啡对Wistar白化大鼠的身体依赖性,在第6天给药后4小时,在皮下注射纳洛酮(2mg /kg, s.c)前15分钟,每天两次腹腔注射增加剂量的吗啡,连续5天。通过腹腔注射安非他酮(5、10和20 mg/kg, i.p)和伐尼克兰(0.5 mg/kg)来评估身体依赖性。1和2mg /kg, s.c) 15分钟。结果:吗啡依赖大鼠的戒断症状明显高于对照组。结果表明,在诱导吗啡依赖期间给予安非他酮和伐尼克兰可减轻大部分戒断症状的严重程度。安非他酮的联合使用减少了戒断症状,如跳跃、湿狗摇晃、体重减轻和全部戒断症状。同时服用伐尼克兰对安非他酮等戒断症状有效,但对体重减轻没有影响。结论:这些结果为安非他酮和伐尼克兰可作为缓解吗啡戒断症状的候选药物提供了初步数据。
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Sıçanlarda Bupropion ve Vareniklinin Morfin Yoksunluğu Sendromu Üzerine Etkileri
Objective: Opioid dependence is a chronic and complex disorder characterized by relapse and remission. Chronic administration of morphine causes symptoms of physical and psychological dependence. The purpose of the present study was to investigate the effect of anti-addictive drugs such as bupropion and varenicline on morphine dependence and naloxone precipitated withdrawal syndrome in a rat model. Materials and Methods: To assess the physical dependence of morphine, Wistar albino rats were intraperitoneal (i.p.) administered increasing doses of morphine twice daily for 5 days, 4 hours after a single dose of morphine on day 6, and 15 minutes before subcutaneous (s.c.) naloxone (2 mg/kg, s.c.) administration to elicit withdrawal symptoms. Physical dependence was evaluated by giving intraperitoneal bupropion (5, 10 and 20 mg/kg, i.p.) and varenicline (0.5. 1 and 2 mg/kg, s.c) for 15 minutes. Results: The morphine-dependent rats had significantly more withdrawal symptoms than naive control rats. The results demonstrated administration of bupropion and varenicline during induction of morphine dependence attenuated the most of the severity of withdrawal symptoms. Co-administration of bupropion reduced withdrawal symptoms such as jumping, wet dog shaking, weight loss and total withdrawal symptoms. Co-administration of varenicline was found to be effective on withdrawal symptoms such as bupropion, but had no effect on weight loss. Conclusion: These outcomes provide preliminary data that bupropion and varenicline could be used as a candidate drugs to attenuate morphine withdrawal symptoms.
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来源期刊
Duzce Medical Journal
Duzce Medical Journal Medicine-Medicine (all)
CiteScore
0.60
自引率
0.00%
发文量
59
审稿时长
12 weeks
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