人脑环核苷酸磷酸二酯酶的三维结构。

Nucleic acids symposium series Pub Date : 2005-12-27 DOI:10.5940/JCRSJ.47.403

Y. Sakamoto, N. Tanaka, T. Ichimiya, T. Kurihara, Kazuo T. Nakamura

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引用次数: 2

摘要

2'，3'-环核苷酸3'-磷酸二酯酶(CNP)主要存在于脊椎动物的中枢神经系统，在体外催化2'，3'-环核苷酸水解生成2'-核苷酸。最近，CNP已被确定为2H磷酸酯酶超家族的成员。在这里，我们以1.3 A的分辨率确定了人类CNP催化片段(hCNP-CF)的晶体结构。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Three-dimensional structure of a cyclic-nucleotide phosphodiesterase from human brain.

2',3'-Cyclic-nucleotide 3'-phosphodiesterase (CNP) is found mainly in the central nervous system of vertebrates and catalyzes the hydrolysis of 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Recently, CNP has been identified as a member of the 2H phosphoesterase superfamily. Here we have determined the crystal structure of the catalytic fragment of human CNP (hCNP-CF) at 1.3 A resolution.

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Nucleic acids symposium series

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