在瑞士小鼠中，高脂肪饮食引起的结肠神经元丢失和运动迟缓与主要微生物群的变化无关

Neurogastroenterology & Motility Pub Date : 2019-11-12 DOI:10.1111/nmo.13745

E. Beraldi, S. Borges, Fernanda Losi Alves de Almeida, Andrey Dos Santos, M. Saad, N. Buttow

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引用次数: 8

摘要

肥胖与胃肠道疾病有关，高脂肪饮食(HFD)引起的肠道肌内神经元的损失被归因于微生物群和脂肪毒性的变化。我们研究了益生元菊糖是否能调节喂食HFD的小鼠的细菌数量并减轻神经元损失。

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Colonic neuronal loss and delayed motility induced by high‐fat diet occur independently of changes in the major groups of microbiota in Swiss mice

Obesity has been linked to gastrointestinal disorders, and the loss of myenteric neurons in the intestine caused by high‐fat diets (HFD) has been attributed to changes in microbiota and lipotoxicity. We investigated whether the prebiotic inulin modulates bacterial populations and alleviates neuronal loss in mice fed HFD.

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Neurogastroenterology & Motility

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