局部注射贝伐单抗(阿瓦斯汀)治疗原发性翼状胬肉的疗效

Mai Abdel Aziz Nasef, Nashwa Saleh, S. Mohamed
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引用次数: 1

摘要

翼状胬肉是结膜对角膜的三角形侵犯。目的本研究旨在评估抗血管内皮生长因子(Avastin)在原发性翼状胬肉治疗中的作用。这是一项介入性研究。这项研究是在AL-Zahraa大学医院眼科进行的。研究时间为2019年10月至2020年9月。本研究纳入了30例原发性翼状胬肉患者的30只眼睛。结果阿瓦斯汀注射前与注射后3个月视力差异均值为−0.10±0.10;病情改善16例(53.3%),稳定14例(46.7%)。阿瓦斯汀注射前与注射后3个月的散光差平均值(- 0.15±0.33);改善10例(33.3%),未改善20例(66.7%)。注射后未见散光增加。从注射后第2周开始到第3个月结束,颜色强度下降非常显著。注射后眼压无明显变化。结论阿瓦斯丁注射液是抑制翼状胬肉进展和改善外观的可行选择,可使翼状胬肉尺寸略有减小,从而改善翼状胬肉产生的散光程度。
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The efficacy of intralesional injection of bevacizumab (Avastin) in the management of primary pterygium
Background Pterygium is a triangular encroachment of the conjunctiva onto the cornea. Objectives This study aimed to assess the role of anti-vascular endothelial growth factor (Avastin) in the management of primary pterygium. Patients and methods This was an interventional study. This study was carried out at the Ophthalmology Department of AL-Zahraa University Hospital. The study period was from October 2019 to September 2020. Thirty eyes from 30 patients with primary pterygia were included in this study. Results There was a difference in visual acuity between preinjection of Avastin and 3 months postinjection by mean −0.10±0.10; 16 patients showed an improvement (53.3%), while 14 patients were stable (46.7%). There is a difference in astigmatism between preinjection of Avastin and 3 months postinjection by mean (−0.15±0.33); 10 patients showed an improvement (33.3%), while 20 patients did not show an improvement (66.7%). No increase in astigmatism occurred in any patient postinjection. There was a highly significant decrease in color intensity starting from the 2nd week till the end of the 3rd month postinjection. There was no significant change in ocular tension postinjection. Conclusion Our results showed that Avastin injection is a viable option in arresting the progress of pterygium and improving the cosmetic appearance, with a slight decrease in pterygium dimensions, which in turn improved the degree of astigmatism produced by pterygium.
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