M. Hossain, S. C. Hall, P. J. Wiggington, S. Roth, S. Das, U. Das, P. K. Roayapalley, J. Dimmock
{"title":"对苯二甲酸的细胞毒性苄基酰肼及其相关化合物。","authors":"M. Hossain, S. C. Hall, P. J. Wiggington, S. Roth, S. Das, U. Das, P. K. Roayapalley, J. Dimmock","doi":"10.1691/ph.2022.11072","DOIUrl":null,"url":null,"abstract":"The present investigation involved the synthesis of a number of novel benzylidene hydrazides as candidate cytotoxic agents. The preparation of these compounds from terephthalic acid and isophthalic acid proceeded satisfactorily. However, the reaction of phthalic acid hydrazide with various aryl aldehydes was unsuccessful in general. Some of the unexpected products were identified. The shapes and also the distances between the centers of the aryl rings designated B and C of three representative compounds 1b, 2b and 3b were determined. The compounds designated 1a-e, 2a-e and 3b were screened against human HCT116 and HT29 colon cancer cells as well as human CRL1790 non-malignant colon cells which revealed the tumor-selective toxicity displayed by these compounds.","PeriodicalId":86039,"journal":{"name":"Die Pharmazie. Beihefte","volume":"10 1","pages":"90-94"},"PeriodicalIF":0.0000,"publicationDate":"2022-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Cytotoxic benzylidene hydrazides of terephthalic acid and related compounds.\",\"authors\":\"M. Hossain, S. C. Hall, P. J. Wiggington, S. Roth, S. Das, U. Das, P. K. Roayapalley, J. Dimmock\",\"doi\":\"10.1691/ph.2022.11072\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The present investigation involved the synthesis of a number of novel benzylidene hydrazides as candidate cytotoxic agents. The preparation of these compounds from terephthalic acid and isophthalic acid proceeded satisfactorily. However, the reaction of phthalic acid hydrazide with various aryl aldehydes was unsuccessful in general. Some of the unexpected products were identified. The shapes and also the distances between the centers of the aryl rings designated B and C of three representative compounds 1b, 2b and 3b were determined. The compounds designated 1a-e, 2a-e and 3b were screened against human HCT116 and HT29 colon cancer cells as well as human CRL1790 non-malignant colon cells which revealed the tumor-selective toxicity displayed by these compounds.\",\"PeriodicalId\":86039,\"journal\":{\"name\":\"Die Pharmazie. Beihefte\",\"volume\":\"10 1\",\"pages\":\"90-94\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Die Pharmazie. Beihefte\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1691/ph.2022.11072\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Die Pharmazie. Beihefte","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1691/ph.2022.11072","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Cytotoxic benzylidene hydrazides of terephthalic acid and related compounds.
The present investigation involved the synthesis of a number of novel benzylidene hydrazides as candidate cytotoxic agents. The preparation of these compounds from terephthalic acid and isophthalic acid proceeded satisfactorily. However, the reaction of phthalic acid hydrazide with various aryl aldehydes was unsuccessful in general. Some of the unexpected products were identified. The shapes and also the distances between the centers of the aryl rings designated B and C of three representative compounds 1b, 2b and 3b were determined. The compounds designated 1a-e, 2a-e and 3b were screened against human HCT116 and HT29 colon cancer cells as well as human CRL1790 non-malignant colon cells which revealed the tumor-selective toxicity displayed by these compounds.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
