The First Affiliated Hospital of Xinjiang Medical University

Objective To analyze the changes of drug resistance of gram- positive cocci in the nearest five years in the First Affiliated Hospital of Xinjiang Medical University. Methods From 2009 to 2013,a total of 1 652 strains of gram-positive cocci were separated out from all kinds of samples of patients hospitalized in the First Affiliated Hospital of Xinjiang Medical University, including Staphylococcus Aureus( MRSA), Enterococcus Faecalis( EFA) and Enterococcus Faecium( EFM). Automatic analyzer( France Biomerieux Company,VITEK- 2 type) and supplementary reagent was used to identify the strains,and drug sensitive test was carried out. WHONET5. 4 software was used to analyze the data. Results The drug resistant rate of MRSA was over 60% to penicillin, oxacillin, gentamicin, levofloxacin, clindamycin, rifampicin,erythromycin,respectively,the average drug resistant rate of MRSA to SMZ- TMP was 21. 8%, no resistant MRSA to vancomycin,teicoplanin and linezolid was found. The drug resistant rate of EFA was low to common antibacterial agents,but that of EFM was higher and higher to common antibacterial agents,average at over 60%,and resistant EFM to vancomycin and teicoplanin were found,but no resistant EFM to linezolid was found. Conclusion Vanomycin,teicoplanin and linezolid are important antibacterial agents for treating multidrug- resistant staphylococcus infection as usual,but the drug resistance of EFM was more serious,which should pay more attention to.