迈向免疫原性热疗作用:调制电热疗

Clinical Oncology and Research Pub Date : 2020-09-18 DOI:10.31487/j.cor.2020.09.07

A. Szász

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引用次数: 4

摘要

热疗治疗实体瘤是一种长期使用，但在临床应用中接受度较低的方法。调制电热疗法(mEHT，商品名:oncothermia®)改变了这种模式，引入了一种新颖的、细胞选择性的和免疫原性的细胞破坏。mEHT方法产生肿瘤疫苗，将癌细胞未损伤的遗传信息呈现给免疫细胞[1]。mEHT方法已在30多个国家获得批准。其II/III期临床应用前景广阔。

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Towards the Immunogenic Hyperthermic Action: Modulated ElectroHyperthermia

Hyperthermia treatment for solid tumors is a long-used, but poorly accepted method in clinical use. Modulated electro-hyperthermia (mEHT, trade name: oncothermia®) changes the paradigm, introduces a novel, cellularly selective and immunogenic cell-ruination. The mEHT method produces tumor-vaccination, presenting the unharmed genetic information of cancer cells to immune cells [1]. The mEHT method is approved in more than 30 countries. Its phase II/III clinical applications indicate a broad perspective.

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Clinical Oncology and Research

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