HIFU对光动力血卟啉衍生物(HPD)的体内激活作用

J. Spoo, J. Jenne, K. Jochle, P. Huber, W. Lorenz, M. Wannenmacher, J. Debus
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引用次数: 0

摘要

作者研究的目的是通过高能超声(HIFU)在体内激活光敏剂,以减少副作用和增加光动力治疗的渗透深度。动物实验采用哥本哈根大鼠邓宁大鼠前列腺癌R3327-AT1进行。评估宏观治疗效果并进行生物学分级。作者能够评估HIFU (f=1.18 MHz, I=3530 W/cm/sup 2/)和血卟啉衍生物的协同组织相互作用。
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In vivo-activation of photodynamic hematoporphyrin-derivative (HPD) by HIFU
The object of the authors' investigations is the in vivo-activation of photosensitizing agents by high energy ultrasound (HIFU) in order to minimize side effects and to increase penetration depth of photodynamic treatments. Animal experiments were carried out using the Dunning rat prostrate adenocarcinoma R3327-AT1 in Copenhagen rats. Macroscopic treatment response was evaluated and biologically graded. The authors were able to assess a synergistic tissue interaction of HIFU (f=1.18 MHz, I=3530 W/cm/sup 2/) and hematoporphyrin-derivative.
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