甲状腺功能减退患者的碘缺乏:一项初步研究

IF 1.7 Q4 ENDOCRINOLOGY & METABOLISM Journal of Thyroid Research Pub Date : 2022-06-02 DOI:10.1155/2022/4328548
K. M. van Veggel, Dina Mehus Ivarson, Jan Maria Martinus Rondeel, G. S. Mijnhout
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引用次数: 1

摘要

在世界范围内,有21个国家的饮食中碘不足。持续缺碘可导致甲状腺功能减退。本研究的目的是确定与对照组相比,碘测量是否可以用于确定(亚临床)甲状腺功能减退患者碘缺乏症的患病率。设计一项前瞻性队列先导研究在Isala内科门诊进行,Isala是荷兰Zwolle的一家大型教学医院。病人。本研究包括两组24名成年患者:一组连续出现明显或亚临床甲状腺功能减退的患者,另一组为1型糖尿病甲状腺功能正常的患者。测量。所有患者均采集24小时尿液。用尿碘浓度(UIC)、尿碘排泄量(UIE)和碘肌酐比(I: Cr)测定碘状态。缺碘定义为UIC碘浓度<100µg/L, UIE碘浓度<125µg, I: Cr碘浓度<0.13µmol/mmol。结果根据UIE和UIC测量,54.2%的甲状腺功能减退患者缺碘,而对照组为41.7-45.8%。根据I: Cr测量,91.7%的甲状腺功能减退患者缺碘,而对照组为87.5%。两组间无显著差异。促甲状腺激素(TSH)水平与缺碘无相关性。结论甲状腺功能减退患者和甲状腺功能正常患者均存在缺碘现象。由于组间无显著差异,单一24小时尿液或尿样测定UIC、UIE和I: Cr似乎不适合测定个体参与者的碘状态。
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Iodine Deficiency in Patients with Hypothyroidism: A Pilot Study
Objective Worldwide, 21 countries have insufficient iodine in their diets. Persistent iodine deficiency may result in hypothyroidism. The aim of this study is to determine whether iodine measurements can be used to determine the prevalence of iodine deficiency in patients with (subclinical) hypothyroidism compared to a control group. Design A prospective cohort pilot study was performed at the Internal Medicine Outpatient Clinic of Isala, a large teaching hospital in Zwolle, the Netherlands. Patients. This study consisted of two groups of 24 adult patients each: a group of consecutive patients presenting with overt or subclinical hypothyroidism and a control group of euthyroid patients with type 1 diabetes mellitus. Measurements. All patients collected 24-hour urine. Iodine status was determined using urinary iodine concentration (UIC), urinary iodine excretion (UIE), and iodine creatinine ratio (I : Cr). Iodine deficiency was defined as an iodine concentration <100 µg/L for UIC, iodine level <125 µg for UIE, and <0.13 µmol/mmol for I : Cr. Results According to UIE and UIC measurements, 54.2% of hypothyroid patients were iodine-deficient compared to 41.7–45.8% in the control group. According to the I : Cr measurement 91.7% of hypothyroid patients were iodine-deficient compared to 87.5% in the control group. No significant difference was seen between the two groups. No correlation was found between thyroid-stimulating hormone (TSH) level and iodine deficiency. Conclusions Iodine deficiency is prevalent in both hypothyroid patients and euthyroid patients. Because there is no significant difference between the groups, a single 24-hour urine or spot urine sample to determine UIC, UIE, and I : Cr, seems not suitable to determine iodine status in an individual participant.
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来源期刊
Journal of Thyroid Research
Journal of Thyroid Research ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
10
审稿时长
17 weeks
期刊最新文献
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