没食子酸可能具有预防肝脏肿瘤前病变发展的潜力

L. Rodríguez-Fragoso
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摘要

图1:显微镜图像显示没食子酸潜在的化学预防作用。大鼠在两周内给予单剂量DEN (200 mg/Kg i.p)和CCl4 (2 mL/ Kg i.p),形成肿瘤前病变。肿瘤前病变表现为显微镜下的小细胞发育不良灶,其特征是肝组织结构丧失,核形态改变,细胞多形性和细胞有丝分裂(箭头)。没食子酸(50 mg/kg p.o.)在诱导肿瘤前病变前5周给予。经没食子酸预处理的动物肝脏形态结构保持不变,未见有丝分裂细胞。在过去的几十年里,一些研究显示了不同多酚在癌症中的化学预防潜力[1]。特别是,没食子酸在体外和体内模型中显示出抗增殖、促凋亡和抗肿瘤等多种抗癌保护特性[2]。没食子酸已被证明对大鼠肝脏肿瘤前病变的发展具有显著的化学预防作用。没食子酸维持肝组织的组织,避免核形态变化的发展,减少细胞的多形性和有丝分裂中的细胞数量(图1)。
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Gallic Acid may have the Potential to Preventing the Development of Preneoplastic Lesions in Liver
Figure 1: Microscopic images show the potential chemopreventive effect of gallic acid. Preneoplastic lesions were developed in rats by administration of a single dose of DEN (200 mg/Kg i.p) and CCl4 (2 mL/kg i.p.) during two weeks. Preneoplastic lesions showed the presence of microscopical small-cell dysplastic focus characterized by loss of liver tissue architecture, changes in nuclear morphology, cellular pleomorphism and cell mitosis (arrows). The gallic acid (50 mg/kg p.o.) was given during five weeks previous to the induction of preneoplastic lesions. Animals pretreated with gallic acid maintained the morphological architecture of liver and no cells in mitosis were observed. In the last decades, several studies have shown the chemopreventive potential of different polyphenols in cancer [1]. Particularly, the gallic acid have shown possess several protective properties anti-cancer as anti-proliferative, pro-apoptotic and anti-tumorigenic effects in vitro and in vivo models [2]. Gallic acid has shown to have a significant chemopreventive effect on development of hepatic preneoplastic lesions in rats. Gallic acid maintains the organization of liver tissue and avoids the development of changes in nuclear morphology, reduces the cellular pleomorphism and the number of cells in mitosis (Figure 1).
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