红树林土壤次生代谢物来源真菌Xylariaceae sp. SCSIO41212

Jingxia HUANG , Ying CHEN , Yanchun HE , Bin YANG
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引用次数: 0

摘要

目的从木耳科真菌SCSIO41212中获得结构新颖且具有生物活性的次生代谢产物。方法采用硅胶柱、Sephadex LH-20、ostade - cysilane (ODS)和半制备高效液相色谱等综合色谱法对化合物进行纯化,并通过理化性质、磁共振成像、波谱分析和文献对比等手段对化合物结构进行鉴定。结果对木质菌Xylariaceae sp. SCSIO41212进行化学鉴定,分离到木油内酯B(1)和木油内酯C(2)两个新化合物,以及9个已知化合物(3-11)。它们的结构是在详细分析一维和二维核磁共振以及质谱数据的基础上确定的。分别对化合物1 ~ 6的抗病毒和细胞毒活性进行了评价。化合物1分别对K562、MCF-7和SGC7901具有较弱的细胞毒性。结论丰富了海洋真菌次生代谢物的多样性,为有前景的新药物先导物的研究提供了重要参考。
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Secondary metabolites from the mangrove soil derived fungus Xylariaceae sp. SCSIO41212

Objective

To obtain structurally novel and bioactive secondary metabolites from the marine fungus Xylariaceae sp. SCSIO41212.

Methods

Compounds were purified by comprehensive chromatography methods of silica gel column, Sephadex LH-20, Ostade-cylsilane (ODS) and semi-preparative HPLC, and their structures were elucidated by means of physical and chemical properties, magnefic resonance imaging, spectroscopic analysis, and comparison with the reported literatures.

Results

Chemical investigation of the fungus Xylariaceae sp. SCSIO41212 has led to the isolation of two new compounds, xylaolide B (1) and xylaolide C (2), together with nine known compounds (3–11). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. Compounds 1–6 were evaluated for their antiviral, and cytotoxic activities, respectively. Compound 1 showed weak cytotoxicities against K562, MCF-7 and SGC7901 respectively.

Conclusion

This study enriches the diversity of secondary metabolites of marine-derived fungi and provides an important reference for novel promising drug leads research.

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