兽医工作人员和宠物主人对猫99mTc-MAG3肾显像的外部暴露

Nattawipa Suwannasaeng, T. Kakizaki, 柿崎竹彦, Seiichi Wada, 和田成一, M. Natsuhori, 夏堀雅宏
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摘要

通过监测猫肾患者(n=20)和对照组(n= 8)在肾显像期间和之后使用99mtc -巯基乙酰甘油三酯(MAG3,剂量93-141 MBq/头)的表面剂量率(SDR)和环境剂量率(ADR),估计兽医核医学工作人员和主人的外部暴露情况。在降解曲线内,SDR在腹侧最高,其生理半衰期为6.01 h。当与患者保持100 cm的距离时,ADR可显著降低约100倍。所有猫在注射后24 h的SDR均小于115 μSv/h,其中累积SDR小于1 mSv(=对公众的剂量限值)。24 h排尿对SDR的影响显著(0.38 ~ 9.6 μSv/h),所有排尿猫的SDR均低于年外部公众暴露限值的1/10。这些结果符合日本的现行立法,而在最大SDR足够低的情况下,24小时的剂量后监管被认为是过度监管。从给动物、它们的主人和兽医诊所造成过重负担的角度来看,根据每个病人的最大SDR确定标准是可取的。
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External Exposure of Veterinary Staffs and Pet Owners from Feline 99mTc-MAG3 Renal Scintigraphy
External exposure of veterinary staffs and owners in veterinary nuclear medicine was estimated by monitoring the surface dose rate (SDR) and ambient dose rate (ADR) from the feline renal patient (n=20) and controls (normal cats, n=8) during and after renal scintigraphy with 99mTc-mercaptoacetyl triglycine (MAG3, dose 93-141 MBq/head). The highest SDR was at the ventral side of abdomen and its SDR-time course followed within the degradation curve with physical half-life (6.01 h) ADR demonstrated significant decrease up to about 100-fold by keeping distance from the patient at 100 cm. All cats showed acceptable SDR which was less than 115 μSv/h in 24 h post injection, where cumulative SDR till infinity was less than 1 mSv (=dose limit to the public). Urination had a conspicuous effect on SDR at 24 h (0.38–9.6 μSv/h) and all urinated cat showed less than 1/10 of the limit of the yearly external public exposure. These results satisfied current legislation in Japan, while the 24 h post-dose regulation was considered over-regulated in the case of sufficiently lower maximum SDR. From the perspective of overburdening animals, their owners, and veterinary clinics, it was considered desirable to determine criteria based on the maximum SDR for each patient.
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