合并和不合并糖尿病的化脓性肝脓肿的临床特点和预后比较:一项病例对照研究

Haitao Sun, Yuxian Yang, E. Klomparens, Dong Zhao
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引用次数: 1

摘要

背景:化脓性肝脓肿(PLA)是一种相对罕见且可能危及生命的疾病。在过去的几十年里,PLA的发病率一直在稳步上升。PLA在糖尿病(DM)患者中比较常见。尽管多项研究已经探讨了PLA和DM之间的关系,但仍然存在争议,证据主要来自病例报告。因此,需要更多的研究来比较PLA合并和不合并DM的患者的特征,以探讨PLA与DM的关系。材料与方法:将2012年12月至2017年8月北京潞河医院收治的115例PLA患者根据是否存在DM分为两组(DM组和非DM组),比较患者的临床特征和结局。使用卡方检验、费雪精确检验和t检验来分析两组之间的差异。结果:纳入的115例患者中,50.4%的患者患有糖尿病。糖尿病组腹痛(28%比51%,P = 0.011)和触诊痛(48%比67%,P = 0.046)的患病率较低。此外,糖尿病组有更高的误诊率(45%对16%,P = 0.001)和不良预后(9%对0%,P = 0.03)。结论:我们发现,与非糖尿病患者相比,糖尿病患者PLA的典型症状可能较少,这可能解释了糖尿病患者PLA误诊率较高的原因,并且糖尿病患者的预后比非糖尿病患者差。
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A comparison of clinical characteristics and outcome in pyogenic liver abscess patients with and without diabetes mellitus: A case-control study
Background: Pyogenic liver abscess (PLA) is a relatively rare and potentially life-threatening disease. The incidence of PLA has been increasing steadily over the past few decades. PLA is relatively common in patients with diabetes mellitus (DM). Although multiple studies have explored the relationship between PLA and DM, it remains controversial, and the evidence comes primarily from case reports. Because of this, more studies are necessary to compare the characteristics of PLA patients with and without DM to explore the relationship between PLA and DM. Materials and Methods: A total of 115 PLA patients admitted in Beijing Luhe Hospital from December 2012 to August 2017 were divided into two groups based on the presence of DM (the DM group and the non-DM group) for the comparison of clinical characteristics and outcomes of patients. Chi-square, Fisher's exact, and t-tests were used to analyze the differences between the two groups. Results: Of 115 patients included, 50.4% of patients had DM. The DM group had a lower prevalence of abdominal pain (28% vs. 51%, P = 0.011) and pain to palpation (48% vs. 67%, P = 0.046). Moreover, the DM group had a higher prevalence of misdiagnosis (45% vs. 16%, P = 0.001) and poor outcomes (9% vs. 0%, P = 0.03). Conclusions: We found that patients with DM may have less typical symptoms of PLA than those without DM, which may explain the higher prevalence of misdiagnosis of PLA in patients with DM. Moreover, patients with DM have worse outcomes than those without DM.
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