Important about the Manipulations of the Pharmaceutical Concerns, the OSMS (One Step Melanoma Surgery) and the Drug Induced Melanoma: "You Dream Things; You Say, 'Why?' But I See Things Before My Eyes; And I Say ‘Why Not?’"

Approach variability in melanoma surgery is more likely to be artificially created and refers mainly to: 1) the surgical safety margins; 2) the clinician’s compliance with the patient’s choice to pre-define these margins for a better cosmetic outcome; 3) the interval within which re-excisions may be carried out; 4)discrepancy between the clinically respected and histologically established tumor resection margins; 5)as well as the lack of additional guidelines for re-excisions within the already established differences between the clinically and histologically established resection margin. These ʺinaccuraciesʺ make it difficult to implement the current guidelines and often lead to confusion. We assume that the approach variability is for sure not established and based only on the opinion of the so-called ‘expert groups’!