Yi Fu, Xin-yan Zhang, M. Cui, Xian-min Liu, Fangxiang Mou
{"title":"aldioxa片对阿司匹林致大鼠胃粘膜损伤的保护作用","authors":"Yi Fu, Xin-yan Zhang, M. Cui, Xian-min Liu, Fangxiang Mou","doi":"10.3760/CMA.J.ISSN.1008-1372.2011.06.014","DOIUrl":null,"url":null,"abstract":"Objective To study the protective effects of aldioxa tablets on ethanol-induced gastric mucosal lesions in rats,and explore the potential pathogenesis.Methods Sixty healthy male Wistar rats were randomly divided into five groups: injury group,control group,sucralfate protective group,aluminium hydroxide protective group and aldioxa protective group.The three protective groups were treated with sucralfate,aluminium hydroxide and aldioxa tablets respectively before to induce gastric mucosal injury.Then the ulcer index,epithelial damage scoring,blood flow of gastric mucosa,the concentration of prostaglandin E2 and nitric oxide of gastric mucosa were measured,and the pathological changes on histological sections and ultrastructural sections of gastric mucosa were assessed under microscope or electron microscope.Results Compared with injury group,the ulcer index and epithelial damage scoring of gastric mucosa significantly decreased in aldioxa protective group(P=0.000,P=0.000),the blood flow of gastric mucosa significantly increased in aldioxa protective group(P=0.000),prostaglandin E2 and nitric oxide concentration of gastric mucosa significantly increased in aldioxa protective group(P=0.000,P=0.001).Conclusion The data revealed that aldioxa tablets had a significant protection effect on rats with acute gastric mucosa injury induced by ethanol,and the increase in blood flow,prostaglandin E2 and nitric oxide concentration maybe contribute to the protective effects.","PeriodicalId":10056,"journal":{"name":"胃肠病学和肝病学杂志","volume":"118 1","pages":"772-775"},"PeriodicalIF":0.0000,"publicationDate":"2011-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Protective effects of aldioxa tablets on aspirin-induced gastric mucosal lesions in rats\",\"authors\":\"Yi Fu, Xin-yan Zhang, M. Cui, Xian-min Liu, Fangxiang Mou\",\"doi\":\"10.3760/CMA.J.ISSN.1008-1372.2011.06.014\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective To study the protective effects of aldioxa tablets on ethanol-induced gastric mucosal lesions in rats,and explore the potential pathogenesis.Methods Sixty healthy male Wistar rats were randomly divided into five groups: injury group,control group,sucralfate protective group,aluminium hydroxide protective group and aldioxa protective group.The three protective groups were treated with sucralfate,aluminium hydroxide and aldioxa tablets respectively before to induce gastric mucosal injury.Then the ulcer index,epithelial damage scoring,blood flow of gastric mucosa,the concentration of prostaglandin E2 and nitric oxide of gastric mucosa were measured,and the pathological changes on histological sections and ultrastructural sections of gastric mucosa were assessed under microscope or electron microscope.Results Compared with injury group,the ulcer index and epithelial damage scoring of gastric mucosa significantly decreased in aldioxa protective group(P=0.000,P=0.000),the blood flow of gastric mucosa significantly increased in aldioxa protective group(P=0.000),prostaglandin E2 and nitric oxide concentration of gastric mucosa significantly increased in aldioxa protective group(P=0.000,P=0.001).Conclusion The data revealed that aldioxa tablets had a significant protection effect on rats with acute gastric mucosa injury induced by ethanol,and the increase in blood flow,prostaglandin E2 and nitric oxide concentration maybe contribute to the protective effects.\",\"PeriodicalId\":10056,\"journal\":{\"name\":\"胃肠病学和肝病学杂志\",\"volume\":\"118 1\",\"pages\":\"772-775\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"胃肠病学和肝病学杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2011.06.014\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"胃肠病学和肝病学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2011.06.014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Protective effects of aldioxa tablets on aspirin-induced gastric mucosal lesions in rats
Objective To study the protective effects of aldioxa tablets on ethanol-induced gastric mucosal lesions in rats,and explore the potential pathogenesis.Methods Sixty healthy male Wistar rats were randomly divided into five groups: injury group,control group,sucralfate protective group,aluminium hydroxide protective group and aldioxa protective group.The three protective groups were treated with sucralfate,aluminium hydroxide and aldioxa tablets respectively before to induce gastric mucosal injury.Then the ulcer index,epithelial damage scoring,blood flow of gastric mucosa,the concentration of prostaglandin E2 and nitric oxide of gastric mucosa were measured,and the pathological changes on histological sections and ultrastructural sections of gastric mucosa were assessed under microscope or electron microscope.Results Compared with injury group,the ulcer index and epithelial damage scoring of gastric mucosa significantly decreased in aldioxa protective group(P=0.000,P=0.000),the blood flow of gastric mucosa significantly increased in aldioxa protective group(P=0.000),prostaglandin E2 and nitric oxide concentration of gastric mucosa significantly increased in aldioxa protective group(P=0.000,P=0.001).Conclusion The data revealed that aldioxa tablets had a significant protection effect on rats with acute gastric mucosa injury induced by ethanol,and the increase in blood flow,prostaglandin E2 and nitric oxide concentration maybe contribute to the protective effects.
期刊介绍：
Chinese Journal of Gastroenterology and Hepatology is a digestive academic journal sponsored by Zhengzhou University. It is open to submissions from home and abroad. The journal was founded in 1992 and officially approved in 1993. It has won the "Second Prize of Henan Province Excellent Science and Technology Journal". It was published quarterly from 1992 to 2002, bimonthly from 2003 to 2007, and monthly from 2008 to date. Since 2002, it has been included in the statistical source journals of scientific and technological papers of the Ministry of Science and Technology (core journals of the Ministry of Science and Technology). The purpose of publishing is to focus on improvement, while paying attention to popularization, striving to achieve popularization and improvement at the same time, following the principle of "improvement as the guide, improvement on the basis of popularization", to guide and promote the development of disciplines. In the publishing process, we pay attention to the advancement, readability, applicability, innovation, orientation, timeliness and policy of the content, and strive to achieve the standardization of editing and publishing.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
