口腔喷雾剂——前景广阔的口腔给药系统研究进展

Chirag I Parmar, N. Joshi, Prachi Modi, P. Bhavsar, Nishtha Desai, Adil Patel
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引用次数: 0

摘要

目的:本综述的目的是收集有关市场上销售的口服喷雾剂及其配方和临床应用的信息。目的:本综述的主要目的是研究市场上销售的用于治疗不同疾病的口服喷雾剂型,并了解其相对于其他口服剂型(如片剂、胶囊、贴剂等)的优势。说明:口服喷雾剂,黏附聚合物,形成小液滴,迅速附着在粘膜表面,使药物容易渗透到血液循环中。由于口腔粘膜的高渗透性,口腔粘膜对许多药物的全身吸收显示出有希望的结果。口服喷雾剂是非常快速,最有效和最简单的方式获得每日剂量的维生素,矿物质和其他营养成分。由于这一优势,口服喷雾剂已成为绕过广泛的首次通过效应的有效选择。结论:口服给药途径是最普遍的给药途径,这是众所周知的事实。然而,广泛的首过代谢和药物在胃中的降解等缺点使得该途径并不适用于所有药物,因此需要一种替代的口服给药系统来解释口服给药途径的好处。许多研究人员正在努力开发口服喷雾制剂,以满足快速渗透和快速起效的要求,并提供传统口服给药系统的有效替代方案。
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Oral Spray – A Review on Promising Drug Delivery System for Oral Cavity
Aim: This review aims to compile information related to marketed oral spray preparation along with their formulation and clinical application. Objective: The main objective of this overview is to study the marketed oral spray dosage form for treatment of different diseases and learn about its advantages over the other oral dosage forms e.g. tablet, capsule, patches etc. Description: Oral spray with Mucoadhesive polymers forms small droplets that quickly adheres to the mucosal surface and let the drug permeate into the blood circulation easily. The oral mucosa has shown promising results for the systemic absorption of many drugs owing to the highly permeable nature of the mucosal membrane. Oral sprays are very fast, the most effective and easy way to get daily dose vitamins, minerals, and other nutrients ingredients. Due to this advantage oral sprays have emerged as an effective alternative for bypassing extensive first pass effect. Conclusion: It has been a very well known fact that the oral route of administration is the most popular route of drug administration. However the drwabacks like extensive first pass metabolism and drug degradation in stomach makes this route not suitable for all drugs and thus an alternative oral drug delivery systems are necessary to explaoint benefits of oral route. Many researchers are working to develop oral spray formulations for drugs which need quick permeation followed by quick onset of action and also provide an effective alternative of conventional oral drug delivery systems.
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