A review on chemistry and biological significance of benzimidaole nucleus

Benzimidazole is a heterocyclic aromatic organic compound. It is an important pharmacophore and privileged structure in medicinal chemistry. It plays a very important role with plenty of useful therapeutic activities such as: antiulcers, antihypertensives, analgesic, anti-inflammatory, anti-virals, antifungals, anticancers, and antihistaminics. The review of the literature shows that the benzimidazole derivatives are outstandingly effective compound and number of reviews available for biochemical and pharmacological studies conformed that their molecules are useful against a wide variety of micro-organisms. Because of their importance, the methods for their synthesis have become a focus of Synthetic Organic Chemists. Therefore in the present review we tried to compile the chemistry of different derivative of substituted benzimidazole as well as various pharmacological activities and some of the important methodologies used for the synthesis. KEYWORDSpharmacophore,Benzimidazole, anti-hypertensive,anti-histaminic,