纳米技术在治疗学和个体化药物中的作用

S. Vats, Meemansha Singh, Sana Siraj, Himani Singh, S. Tandon
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引用次数: 23

摘要

为改善卫生保健的诊断和治疗系统进行了各种研究。新的和先进的技术更多地集中在诊断和识别疾病,然后提供与诊断药物本身结合的有效治疗。基于纳米疗法和个性化药物的治疗确实具有更好的预后,并防止因诊断晚而使可治愈的疾病变成致命的疾病,特别是对第三世界国家的普通穷人。在癌症治疗中,分离各种生物液体和肿瘤,然后分析各种生物标志物,如可溶性标志物、免疫组织复合物、突变基因产物蛋白质、改变的蛋白质、抗原或不同表达的蛋白质。及时提供治疗在很大程度上取决于高特异性和准确性的及时诊断。改进的诊断有助于预先筛选目标分子的概况,以开发基于疾病特异性治疗的生物标志物。使其成本更低,脱靶毒性更小,疗效和特异性更高,可实时分析以进行深入观察和指导,并研究其作用和副作用以制定进一步的治疗方案。这篇综述更侧重于个体化治疗方法。
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Role of nanotechnology in theranostics and personalized medicines
Various researches have been conducted for the improvement of diagnostics and therapeutic systems of health care. Novel and advanced technologies focus more on diagnosing and identifying diseases and then providing an effective therapy conjugated with the diagnostic agents itself. Theranostics based on nanotherpay with personalized medicines do have better prognosis and prevent turning up of curable disease into fatal one due to late diagnosis, especially for the common poor from the third world nations. In the treatment of cancers, various biofluids and tumors are isolated and then analyzed for various biomarkers such as soluble markers, immune histocomplexes, proteins as products from mutated genes, altered proteins, antigens, or differently expressed proteins. Providing treatment on right time depends very much on right-time diagnosis with high specificity and accuracy. Improved diagnosis helps in prescreening the profile of target molecules to develop biomarkers based on disease-specific therapy. With making it the less expensive, with less off-target toxicity and high efficacy and specificity, with real-time analysis for thorough observation and guidance and studying effects and side effects to develop further therapeutic options. This review focuses more on personalized medicines with theranostic approach.
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