耐甲氧西林金黄色葡萄球菌(MRSA):室外和室内患者的患病率和抗菌药物敏感性模式孟加拉国达卡市医院

M. Rahman, Kohinoor Akter Raton, Md. Asif Hossain
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摘要

耐甲氧西林金黄色葡萄球菌(MRSA)是世界上引起公共卫生关注的重要病原体之一。本研究针对孟加拉国达卡Sirajul Islam医学院和医院不同年龄和性别临床病史的室内和室外患者的MRSA流行情况及其抗生素耐药性进行了研究。我们在2019年1月至2019年7月期间进行。共964份样本,其中室外354份(36.72%)室内610份(63.27%)。观察5天(BACTEC-9050 Machine),然后选择性接种到血琼脂培养基上,培养板37℃孵育24小时。在血琼脂上显示金黄色的金黄色葡萄球菌菌落初步鉴定为金黄色葡萄球菌,然后进行过氧化氢酶和凝固酶试验。耐甲氧西林金黄色葡萄球菌(MRSA)在室外和室内患者中仅检出42例(4.35%),其中男性18例,女性24例;(MSSA) 50例(5.18%)、假单胞菌14例(1.45%)、克雷伯氏菌13例(1.34%)、沙门氏菌27例(2.80%)、大肠杆菌21例(2.17%),未检出MRSA、MSSA等微生物797例(82.67%)。共鉴定出MRSA金黄色葡萄球菌。所有血液样本中42例(4%),其他922例(96%)。代表多重16种药物的标准抗菌纸片对以下抗生素的敏感性为381(56.69%),耐药性为284 (42.26%),middle -7(1.04%)分别为:奥西林、万古霉素、红霉素、复方新诺明、环丙沙星、庆大霉素、利奈唑胺、阿莫西林、阿莫克拉夫、阿奇霉素、亚胺培南、美罗培南、那替米星、加替沙星、氯西林、斯帕沙星。在这项研究中,我们描述了目前的负担MRSA感染在医疗保健和社区孟加拉国。并设定了其他国家最近MRSA流行病学变化造成的主要威胁。该数据对患者护理质量、抗生素选择和感染控制实践具有重要意义。
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Methicillin-Resistant Staphylococcus aureus (MRSA): Prevalence and Antimicrobial Sensitivity Pattern among Outdoor and Indoor Patients Dhaka City Hospital Bangladesh
Methicillin-Resistant S. aureus (MRSA) is one of the significant pathogens with associated public-health concern in the world. The present study has been focused on the prevalence of MRSA and their antibiotic resistance of indoor and outdoor patients different age & gender in clinical history, Dr. Sirajul Islam medical college and hospital Dhaka, Bangladesh. We were performed during the period of January 2019 to July 2019. A total 964 samples which is outdoor 354 (36.72%) indoor 610 (63.27%). We were observation 5 days (BACTEC-9050 Machine) then inoculated selective onto Blood agar media and the culture plates were incubated at 37°C for 24 h. The S. aureus colonies showing golden yellow colour on Blood agar were primarily identified as S. aureus, which were then subjected for catalase and coagulase tests. The Methicillin-Resistant S. aureus (MRSA) could be detected outdoor and indoor patients only 42 (4.35%) into, males 18 and female 24 in total sample, on the other hand S. aureus. (MSSA) 50 (5.18%), Pseudomonas spp. 14 (1.45%), Klebsiella spp. 13 (1.34%), Salmonella spp. 27 (2.80%), E. coli 21 (2.17%), no MRSA, MSSA and other organisms are found 797 (82.67%). Total identified MRSA Staphylococci aureus. 42 (4%) in all blood samples, and other 922 (96%). Standard antimicrobial disks representing multiple sixteen drug were, Sensitive-381 (56.69%), Resistance-284 (42.26%), as well as Intermediate-7 (1.04%) against antibiotics, Oxacillin, Vancomycin, Erythromycin, Co-trimoxazole, Ciprofloxacin, Gentamicin, Linezolid, Amoxicillin, Amoxyclave, Azithromycin, Imipenem, Meropenem, Netilmicin, Gatifloxacin, Cloxacillin, Sparfloxacin. In this study, we describe the current burden of MRSA infections in healthcare and community of Bangladesh. And settings across other country the main threats caused by recent changes in the epidemiology of MRSA. This data has important implication for quality of patients care antibiotic selection and infection control practices.
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