抗脾酪氨酸激酶类黄酮治疗银屑病的鉴定:硅片法

S. Pol, V. Kadam, S. Jagtap, Sampada Bhosale, Nita Pawar, R. Gaikwad
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引用次数: 0

摘要

目前,植物化学物质被广泛用于结构优化方案,其重点是生产活性更强、毒性更低的药物。牛皮癣是一种炎症性、慢性、缓解性和复发性、遗传影响的皮肤病。利用各种黄酮类化合物的结构来寻找抗银屑病的潜在分子。本研究通过分子对接研究,鉴定与银屑病靶蛋白结合能力较好的黄酮类化合物。利用药物相似性预测方法对对接配体的类药物性质进行了鉴定。结果表明,23种黄酮类化合物可能对银屑病有一定的治疗作用。
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Identification of Potential Flavonoids against the Spleen Tyrosine Kinase to Treat Psoriasis: In Silico approach
Now a day, phytochemicals are widely consideration for structure optimization programs which focuses on making more active and less toxic drug products. Psoriasis is an inflammatory, chronic, remitting and relapsing, genetically influenced skin disease. Variety of flavonoid structureswere used to find the potential molecules against the psoriasis. In this current study molecular docking studies were carried out to identify the flavonoids having good binding ability with the target protein of psoriasis. Docked ligands were subjected to identify the drug like properties using drug-likeness prediction. Findings suggested that 23 flavonoid structures may act against the psoriasis.
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