番泻草乳剂:化学烧伤治疗的草药替代品

J. Isaac, Aisha Daburi, Benneth Ifeanyi, K. Ben-Umeh, Abiodun Abigail Adedokun, P. Builders
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引用次数: 3

摘要

番泻叶在民间医药中用于烧伤和伤口的治疗,用作伤口表面的膏药。然而,据我们所知,这种植物的伤口愈合能力还没有得到科学的评估。本工作旨在确定SP叶粗提物的创面愈合潜力,并评价其制备成乳状物的效益。本研究以2.5% SP乳液(F1)和7.5% SP乳液(F2)为配方,将乳液相与凝胶相按1:1的比例混合,然后测定其物理外观、小球大小、pH、粘度、溶胀性、水活度、挤压性、遮挡性、展布性、稳定性和伤口愈合能力。植物化学筛选表明,SP叶水乙醇提取物中含有生物碱、皂苷、单宁、心苷、黄酮类、蒽醌类和酚类物质,黄酮类含量高被认为是其愈合特性的原因。我们的配方显示出可接受的物理性质。苏木精-伊红和verhoefff - van Gieson染色显示,F2可诱导盐酸损伤小鼠伤口愈合过程中成纤维细胞、纤维细胞、炎症细胞、腺体细胞、表皮细胞、脂肪细胞和胶原蛋白的积累。令人鼓舞的是,用F1、F2和SP叶膏药治疗的小鼠伤口收缩的百分比分别为64%、87%和50%,这表明SP乳膏比SP叶膏药表现出更好的愈合性能,这可能是由于凝胶的闭塞性。综上所述,SP叶粗提物F2对烧伤和创面愈合具有较好的药理作用,可能是未来治疗烧伤创面的首选。
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Senna podocarpa Emulgel: A Herbal Alternative for Chemical Burn Wound Treatment
Senna podocarpa (SP) leaves are used in folk medicines for treatment of burns and wounds as poultices on wound surface. However, to the best of our knowledge, the wound healing ability of this plant has not been scientifically evaluated. This work aimed to determine the wound healing potential of the crude extract of SP leaves, and to evaluate the benefit of its preparation as an emulgel. In this study, the formulations of 2.5% of SP emulgel (F1) and 7.5% of SP emulgel (F2) were prepared by mixing the emulsion phase with the gel phase in a ratio of 1:1, and then physical appearance, globule size, pH, viscosity, swelling, water activity, extrudability, occlusion, spreadability, stability, and wound healing ability were determined. Phytochemical screening showed the presence of alkaloids, saponins, tannins, cardiac glycosides, flavonoids, anthraquinones, and phenols within the hydro-ethanolic extract of SP leaves, and high flavonoid content is believed to be responsible for its healing attributes. Our formulations showed acceptable physical properties. Hematoxylin-eosin and Verhoeff–Van Gieson stain showed that F2 could induce the accumulation of fibroblasts, fibrocytes, inflammatory cells, gland cells, epidermal cells, adipocytes, and collagen in the process of wound healing in mice injured with hydrochloric acid. Encouragingly, the percent of wound contractions in mice treated with F1, F2, and SP leaf poultice were 64, 87, and 50, respectively, suggesting the superior healing properties exhibited by SP emulgel over SP leaf poultice, and this may due to the occlusive property of emulgels. In conclusion, F2 of crude extract of SP leaves has better pharmacological effects on burn and wound healing, and may represent a preferred choice to treat burn wounds in the future.
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