一些三唑[3,4-b][1,3,4]噻二唑的抗癌性质

Q2 Chemistry Current Chemistry Letters Pub Date : 2023-01-01 DOI:10.5267/j.ccl.2023.4.001

I. Myrko, T. Chaban, Y. Horak, olodymyr Ogurtsov, I. Drapak, I. Chaban, V. Matiychuk

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引用次数: 0

摘要

本文报道了几种新型3- r -6-(5-芳基呋喃-2-基-[1,2,4]三唑[3,4-b][1,3,4]噻二唑的高效合成及其抗癌活性评价。我们已经证明，所提出的合成方案提供了设计具有相当化学新颖性的三唑噻唑多样性的可能性。通过1H NMR谱、质谱和元素分析等手段对目标物质的结构进行了确证。合成的化合物经美国国家癌症研究所发育治疗项目筛选，用于体外细胞系筛选。在所有被测物质中，有三种化合物表现出显著的细胞毒活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Anticancer properties of some triazolo[3,4-b][1,3,4]thiadiazoles

In the present work, we presented an efficient synthesis and anticancer activity evaluation of some new 3-R-6-(5-arylfuran-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. We have shown that the proposed synthetic protocols provided the possibility to design triazolothiadiazoles diversity with a considerable chemical novelty. The structures of target substances were confirmed by using 1H NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds were selected by the National Cancer Institute Developmental Therapeutic Program for the in vitro cell line screening. Among all the substances tested, three compounds exhibited significant cytotoxic activity.

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来源期刊

Current Chemistry Letters Chemistry-Chemistry (all)

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The "Current Chemistry Letters" is a peer-reviewed international journal which aims to publish all the current and outstanding research articles, reviews and letters in chemistry including analytical chemistry, green chemistry, inorganic chemistry, organic chemistry, physical chemistry, etc. This journal is dedicated to serve all academic and industrial researchers and scientists who are expert in all major advances in chemistry research. The journal aims to provide the most complete and reliable source of information on current developments in these fields. The emphasis will be on publishing quality articles rapidly and openly available to researchers worldwide. Please note readers are free to read, download, copy, distribute, print, search, or link to the full texts of articles published on this journal. Current Chemistry Letters is an open access journal, which provides instant access to the full text of research papers without any need for a subscription to the journal where the papers are published. Therefore, anyone has the opportunity to copy, use, redistribute, transmit/display the work publicly and to distribute derivative works, in any sort of digital form for any responsible purpose, subject to appropriate attribution of authorship. Authors who publish their articles may also maintain the copyright of their articles.