N. Inaba, N. Satoh, R. Ohkawa, K. Kizawa, S. Sekiya, Junkoh Kudoh, H. Takamizawa
{"title":"妇科手术中纤维蛋白溶解系统的局部和全身变化及福伊对这些变化的影响","authors":"N. Inaba, N. Satoh, R. Ohkawa, K. Kizawa, S. Sekiya, Junkoh Kudoh, H. Takamizawa","doi":"10.1111/J.1447-0756.1981.TB00524.X","DOIUrl":null,"url":null,"abstract":"We used basilic and uterine vein blood samples to study local and systemic changes in the fibrinolytic system of 30 patients undergoing gynecological surgery and evaluated the effectiveness of preoperative administration of ethyl-p- (6-guanidino hexanoyloxy) benzoate methanesulfonate (FOY) in reducing surgery related bleeding. Our results confirm that fibrinolytic activity tends to increase during gynecological surgery and also suggest that basilic vein blood is not a reliable indicator of local fibrinolytic activity. The systemic administration of 5.0 – 7.5 mg/kg FOY was found to inhibit local fibrinolytic activity during abdominal hysterectomy and no serious side effects were observed.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"2 1","pages":"175-184"},"PeriodicalIF":0.0000,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Local and Systemic Changes in the Fibrinolytic System During Gynecological Surgery and the Effect of Foy on these Changes\",\"authors\":\"N. Inaba, N. Satoh, R. Ohkawa, K. Kizawa, S. Sekiya, Junkoh Kudoh, H. Takamizawa\",\"doi\":\"10.1111/J.1447-0756.1981.TB00524.X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We used basilic and uterine vein blood samples to study local and systemic changes in the fibrinolytic system of 30 patients undergoing gynecological surgery and evaluated the effectiveness of preoperative administration of ethyl-p- (6-guanidino hexanoyloxy) benzoate methanesulfonate (FOY) in reducing surgery related bleeding. Our results confirm that fibrinolytic activity tends to increase during gynecological surgery and also suggest that basilic vein blood is not a reliable indicator of local fibrinolytic activity. The systemic administration of 5.0 – 7.5 mg/kg FOY was found to inhibit local fibrinolytic activity during abdominal hysterectomy and no serious side effects were observed.\",\"PeriodicalId\":8557,\"journal\":{\"name\":\"Asia-Oceania journal of obstetrics and gynaecology\",\"volume\":\"2 1\",\"pages\":\"175-184\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-05-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asia-Oceania journal of obstetrics and gynaecology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/J.1447-0756.1981.TB00524.X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asia-Oceania journal of obstetrics and gynaecology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/J.1447-0756.1981.TB00524.X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Local and Systemic Changes in the Fibrinolytic System During Gynecological Surgery and the Effect of Foy on these Changes
We used basilic and uterine vein blood samples to study local and systemic changes in the fibrinolytic system of 30 patients undergoing gynecological surgery and evaluated the effectiveness of preoperative administration of ethyl-p- (6-guanidino hexanoyloxy) benzoate methanesulfonate (FOY) in reducing surgery related bleeding. Our results confirm that fibrinolytic activity tends to increase during gynecological surgery and also suggest that basilic vein blood is not a reliable indicator of local fibrinolytic activity. The systemic administration of 5.0 – 7.5 mg/kg FOY was found to inhibit local fibrinolytic activity during abdominal hysterectomy and no serious side effects were observed.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
