Efficacy and Safety of Autologous Platelets Concentrated in the Treatment of Perioral Skin Aging.

Introduction: The rejuvenation of the perioral region has a certain degree of difficulty. The search for painless and minimally invasive alternatives is a challenge in the field of aesthetic medicine. Objective: To evaluate the efficacy and safety of intradermal microinjection of autologous platelet concentrate (APC) in the treatment of perioral skin aging signs. Method: An observational, analytical and longitudinal study was carried out in 60 patients from the Hospital Clínico Quirúrgico: “Hermanos Ameijeiras”, in the period between March 1, 2017 and March 31, 2020. The treatment was applied monthly. For 1 year. The final evaluation was carried out 3 months after the end of the treatment. Results: 60 women with an average age of 45 ± 4.3 years were treated. After treatment, there were significant changes in the Glogau Photo Damage Scale (P = 0.028), in the Global Aesthetic Improvement Scale (P <0.032) and in the Evaluative Scale of the severity range of the nasolabial fold (P = 0.031). The adverse events found were pain, inflammation and ecchymosis. The degree of satisfaction reported by the patients was good (16.7%) and very good (83.8%) (P <0.038). Conclusions: The autologous platelet concentrate proved to be effective and safe to reduce the signs of perioral skin aging, associated with a high degree of patient satisfaction.