The influence of sodium and potassium doping effect on phase formation in calcium sulphate synthesis

Calcium sulphate-based materials were synthesized and investigated, in which Ca2+ cations were substituted for Na+ or K+ cations in an amount of 5, 10 and 20 mol.%. With the introduction of Na+, materials with the structure semi-aqueous and two-water calcium sulfate were obtained, with the introduction of potassium, a mixture of calcium sulfates with different content of chemically bound water and sulfates were obtained, in which potassium cations are forming compounds with different Ca/K ratio. Doping of calcium sulphate with potassium and sodium cations led to an increase in the solubility of materials: for sodium-containing ones by 1,2 times, for potassium-containing ones by 3-4 times. The developed materials are promising for use in medicine for filling bone tissue defects, and can also be used as a cement matrix for targeted drug delivery.