{"title":"使用钪-44放射标记PSMA-617的治疗前剂量测定","authors":"E. Eppard","doi":"10.5772/INTECHOPEN.79157","DOIUrl":null,"url":null,"abstract":"In recent years, the positron emitter scandium-44 moved into the focus of research pro- viding favorable nuclide properties for an application in nuclear medicine. Radiolabeling of PSMA-617 with scandium-44 as diagnostic match for [ 177 Lu]Lu-PSMA-617 instead of gallium-68 would enable pre-therapeutic dosimetry in clinical setting. Due to the chemical similarities of scandium and lutetium, the in vitro and in vivo characteristics of [ 177 Lu]Lu-PSMA-617 are more similar to [ 44 Sc]Sc-PSMA-617 than to the 68 Ga-compounds [ 68 Ga]Ga-PSMA-617 or [ 68 Ga]Ga-PSMA-11. [ 44 Sc]Sc-PSMA-617 showed its potential in a clinical setting as a PET imaging agent of prostate cancer providing several advan- tages over gallium-68 labeled tracers. The longer half-life of the nuclide would allow, for example, an optimized patient management and treatment, long-term or late time point imaging as well as transportation to more distant PET centers. However, especially clinical applications like individual dosimetry or intraoperative applications are still under investigation.","PeriodicalId":20788,"journal":{"name":"Prostatectomy","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Pre-Therapeutic Dosimetry Employing Scandium-44 for Radiolabeling PSMA-617\",\"authors\":\"E. Eppard\",\"doi\":\"10.5772/INTECHOPEN.79157\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In recent years, the positron emitter scandium-44 moved into the focus of research pro- viding favorable nuclide properties for an application in nuclear medicine. Radiolabeling of PSMA-617 with scandium-44 as diagnostic match for [ 177 Lu]Lu-PSMA-617 instead of gallium-68 would enable pre-therapeutic dosimetry in clinical setting. Due to the chemical similarities of scandium and lutetium, the in vitro and in vivo characteristics of [ 177 Lu]Lu-PSMA-617 are more similar to [ 44 Sc]Sc-PSMA-617 than to the 68 Ga-compounds [ 68 Ga]Ga-PSMA-617 or [ 68 Ga]Ga-PSMA-11. [ 44 Sc]Sc-PSMA-617 showed its potential in a clinical setting as a PET imaging agent of prostate cancer providing several advan- tages over gallium-68 labeled tracers. The longer half-life of the nuclide would allow, for example, an optimized patient management and treatment, long-term or late time point imaging as well as transportation to more distant PET centers. However, especially clinical applications like individual dosimetry or intraoperative applications are still under investigation.\",\"PeriodicalId\":20788,\"journal\":{\"name\":\"Prostatectomy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-11-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostatectomy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5772/INTECHOPEN.79157\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostatectomy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5772/INTECHOPEN.79157","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Pre-Therapeutic Dosimetry Employing Scandium-44 for Radiolabeling PSMA-617
In recent years, the positron emitter scandium-44 moved into the focus of research pro- viding favorable nuclide properties for an application in nuclear medicine. Radiolabeling of PSMA-617 with scandium-44 as diagnostic match for [ 177 Lu]Lu-PSMA-617 instead of gallium-68 would enable pre-therapeutic dosimetry in clinical setting. Due to the chemical similarities of scandium and lutetium, the in vitro and in vivo characteristics of [ 177 Lu]Lu-PSMA-617 are more similar to [ 44 Sc]Sc-PSMA-617 than to the 68 Ga-compounds [ 68 Ga]Ga-PSMA-617 or [ 68 Ga]Ga-PSMA-11. [ 44 Sc]Sc-PSMA-617 showed its potential in a clinical setting as a PET imaging agent of prostate cancer providing several advan- tages over gallium-68 labeled tracers. The longer half-life of the nuclide would allow, for example, an optimized patient management and treatment, long-term or late time point imaging as well as transportation to more distant PET centers. However, especially clinical applications like individual dosimetry or intraoperative applications are still under investigation.
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