{"title":"印楝油对小鼠伯氏疟原虫生长的抑制作用","authors":"C. Nyamwange, J. Maina, Hs Nyandieka","doi":"10.4314/ECAJPS.V10I3.9763","DOIUrl":null,"url":null,"abstract":"Although neem oil extract is widely used in Africa and Asia for the treatment and prevention of malaria, its inhibitory effect on the growth of malaria parasites in vivo has not been fully tested. In the present study, the inhibitory effects of neem oil extract against the growth of rodent malaria parasite in the mice were investigated. The results revealed that administration of neem oil to the mice infected by rodent malaria parasite reduces the rate of development of Plasmodium berghei . These results show that neem oil extract could be an effective antimalarial agent in humans that merits further investigations using human parasites. Keywords : Neem oil, inhibitory effect, Plasmodium berghei , mice East and Central African Journal of Pharmaceutical Sciences Vol. 10 (3) 2007: pp. 56-58","PeriodicalId":22387,"journal":{"name":"The East and Central African Journal of Pharmaceutical Sciences","volume":"119 1","pages":"56-58"},"PeriodicalIF":0.0000,"publicationDate":"2008-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Inhibitory Effects of Neem Oil against the Development of Plasmodium berghei in Mice\",\"authors\":\"C. Nyamwange, J. Maina, Hs Nyandieka\",\"doi\":\"10.4314/ECAJPS.V10I3.9763\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Although neem oil extract is widely used in Africa and Asia for the treatment and prevention of malaria, its inhibitory effect on the growth of malaria parasites in vivo has not been fully tested. In the present study, the inhibitory effects of neem oil extract against the growth of rodent malaria parasite in the mice were investigated. The results revealed that administration of neem oil to the mice infected by rodent malaria parasite reduces the rate of development of Plasmodium berghei . These results show that neem oil extract could be an effective antimalarial agent in humans that merits further investigations using human parasites. Keywords : Neem oil, inhibitory effect, Plasmodium berghei , mice East and Central African Journal of Pharmaceutical Sciences Vol. 10 (3) 2007: pp. 56-58\",\"PeriodicalId\":22387,\"journal\":{\"name\":\"The East and Central African Journal of Pharmaceutical Sciences\",\"volume\":\"119 1\",\"pages\":\"56-58\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The East and Central African Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/ECAJPS.V10I3.9763\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The East and Central African Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/ECAJPS.V10I3.9763","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
虽然印楝油提取物在非洲和亚洲被广泛用于治疗和预防疟疾，但其对疟原虫体内生长的抑制作用尚未得到充分的测试。本文研究了印楝油提取物对小鼠体内啮齿动物疟原虫生长的抑制作用。结果表明，对感染啮齿动物疟原虫的小鼠施用印楝油可降低伯氏疟原虫的发展速度。这些结果表明，印楝油提取物可能是一种有效的人类抗疟剂，值得利用人类寄生虫进行进一步的研究。关键词:印楝油，抑制作用，伯氏疟原虫，小鼠东非和中非药学杂志Vol. 10 (3) 2007: pp. 56-58
The Inhibitory Effects of Neem Oil against the Development of Plasmodium berghei in Mice
Although neem oil extract is widely used in Africa and Asia for the treatment and prevention of malaria, its inhibitory effect on the growth of malaria parasites in vivo has not been fully tested. In the present study, the inhibitory effects of neem oil extract against the growth of rodent malaria parasite in the mice were investigated. The results revealed that administration of neem oil to the mice infected by rodent malaria parasite reduces the rate of development of Plasmodium berghei . These results show that neem oil extract could be an effective antimalarial agent in humans that merits further investigations using human parasites. Keywords : Neem oil, inhibitory effect, Plasmodium berghei , mice East and Central African Journal of Pharmaceutical Sciences Vol. 10 (3) 2007: pp. 56-58
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