近亲婚姻对慢性肾病小肾的影响

Semahat rali
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摘要

目的:探讨小肾和近亲婚姻在慢性肾病(CKD)中的作用。材料与方法:纳入2021年9月至2022年9月在门诊申请的肾垂直尺寸小于100mm的患者。尿超和肾功能检查间隔一年记录。对两组有亲戚和没有亲戚的人进行比较。采用SPSS 22.0软件进行统计。P < 0.05被认为是显著的。结果:本组94例小肾患者中,父母有亲属关系的50例,无亲属关系的44例。57.4%为女性,平均年龄49.86岁。比较有和无亲代血亲关系组间用于慢性肾病进展随访的尿素、肌酐、e-GFR、血红蛋白、白蛋白、磷、钙、甲状旁腺素、铁蛋白和尿USG。结论:在肾功能不全建立前,早期应用超声检查近亲婚姻相关小肾的预防措施,可减缓病情发展。
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The Effects of Consanguineous Marriage on Small Kidney in Chronic Kidney Disease Small Kidneys in Chronic Kidney Disease
Aim: To determine the effects of small kidney and consanguineous marriage in chronic kidney disease (CKD). Materials and Methods: Patients with a vertical kidney size of 100 mm or less, who applied to the outpatient clinic between September 2021 and 2022, were included in the study. Urinary ultrasonography and renal function tests were recorded one year apart. Two groups, with and without relatives, were compared. SPSS 22.0 program was used for statistics. p< .05 was considered significant. Results: The parents of 50 of the 94 cases with small kidney included in the study were related and 44 of them were not related. 57.4% were female, mean age was 49.86. Urea, creatinine, e-GFR, hemoglobin, albumin, phosphorus, calcium, PTH, ferritin, and urinary USG used in chronic kidney disease progression follow-up were compared between the groups with and without parental consanguinity. Conclusion: Early application of prevention measures with ultrasound detection of small kidney related to consanguineous marriage at an earlier age before kidney dysfunction is established will slow down the progression.
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