新冠病毒抗病毒药物瑞德西韦研究进展

S. Nimesh, S. Bharat, Mehta Abhay, S. Sandeep, P. Archna
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引用次数: 0

摘要

到目前为止,2019年初发现的冠状病毒感染已经阻碍了世界的目标。全球感染病例数量已增至350万,因此全球卫生组织将此次疫情描述为大流行,但迄今为止还没有任何“特定药物”或疫苗可用。相关报道发现了一种新型冠状病毒,与SARS有80%的同源性。因此,当其他国家使用抗病毒药物Remdesivir时,几乎没有可用的适应症。治疗2019年急性冠状病毒病(COVID-19)患者的特定抗病毒药物方案尚未得到证实。雷德西韦(GS-5734)是一种核苷类似物,在体外对包括急性呼吸综合征冠状病毒2 (SARS-CoV-2)和中东呼吸综合征(NiR)在内的致病性动物和人类冠状病毒有抑制作用。-1和SARS-CoV-2在动物模型中的复制。
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A Review on Remdesivir: An Alternative Antiviral Drug to Fight against COVID-19
A coronavirus infection that was discovered in early 2019 has already hampered the world’s purpose so far. The number of infectious cases has grown worldwide to 35 lakhs and so the outbreak has been described as a pandemic by the planet’s health organization, but there have not been any “specific drugs” or vaccines available to date. Relevant reports have identified a novel coronavirus with 80% homology with SARS. So there are few indications available when other countries are using the antiviral drug Remdesivir. The specific antiviral drug regimen for the treatment of patients with acute coronavirus disease 2019 (COVID-19) has not been proven. Remdecivir (GS-5734), a nucleoside analog product, has inhibitory effects on pathogenic animal and human coronaviruses including acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro , and Middle East respiratory syndrome, NiR. -1, and SARS-CoV-2 replication in animal models.
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