抗血小板药物对狭窄血管血流的影响

S. R. Shah
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引用次数: 0

摘要

抗血小板药物通过防止血小板在动脉内聚集来阻止血栓的形成,特别是对那些动脉有动脉粥样硬化或动脉容易形成血栓的人来说。动脉粥样硬化是一种慢性疾病,动脉会堵塞和硬化。脂肪、胆固醇、钙和其他物质形成斑块,在动脉中积聚。硬斑块使血液流动的通道变窄。这会导致动脉变得坚硬和不灵活。软斑块更容易从动脉壁上脱离,形成血栓,从而阻碍血液流向重要器官。本文采用Herschel-Bulkely流体模型,探讨抗血小板药物对狭窄动脉血流的影响及非牛顿黏度的意义。文中最后给出了数值算例,通过图形表示给出了流动阻力、表观黏度和壁面剪应力的计算结果。
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Effects of Antiplatelet Drugs on Blood Flow through Stenosed Blood Vessels
Antiplatelet drugs block the formation of blood clots by preventing the clumping of platelets inside arteries, particularly in individuals who have atherosclerosis of their arteries, or are otherwise prone to develop blood clots in their arteries. Atherosclerosis is a slow disease in which arteries become clogged and hardened. Fat, cholesterol, calcium, and other substances form plaque, which builds up in arteries. Hard plaque narrows the passage that blood flows through. That causes arteries to become hard and inflexible. Soft plaque is more likely to break free from the artery wall and cause a blood clot, which can block blood flow to vital organs. In this paper an attempt has been made to investigate the effects of antiplatelet drugs on blood flow and significance of non-Newtonian viscosity through a stenosed artery using Herschel-Bulkely fluid model. Numerical illustration presented at the end of the paper provides the results for the resistance to flow, apparent viscosity and the wall shear stress through their graphical representations.
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