基于微室的三维多层微结构药物释放模型

2007 7th IEEE Conference on Nanotechnology (IEEE NANO) Pub Date : 2007-08-01 DOI:10.1109/NANO.2007.4601253

R. Yu, Hualing Chen, Tianning Chen, Xiangyang Zhou

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引用次数: 2

摘要

本文建立了具有大微室阵列的三维可生物降解多层给药微结构的数学模型。利用元胞自动机(CA)和离散迭代对这种药物传递微观结构中多种药物的同时释放进行建模。该模型可以描述药物释放的动态行为。此外，还对两种药物封闭的药物传递结构进行了模拟。仿真结果表明，所建立的数学模型可作为三维生物可降解多层给药微观结构优化设计方法的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Modeling the drug release from 3D multi-layer microstructure with micro-chambers

This paper presents a mathematical model for three-dimensional biodegradable multi-layer drug delivery microstructure with large array of micro-chambers. The simultaneous release of multiple drugs from this type of drug delivery microstructure is modeled using cellular automata (CA) and discrete iterations. The model can describe the dynamic behavior of drug release. Furthermore, simulations about this type of drug delivery microstructure enclosed two drugs are carried out. The simulation results show that the introduced mathematical model can act as the basis of a new optimal design methodology for three-dimensional biodegradable multi-layer drug delivery microstructure.

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2007 7th IEEE Conference on Nanotechnology (IEEE NANO)

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