直接口服抗凝血剂的药物遗传学特点及其使用和疗效现状

E. Gantsgorn, A. Safronenko, E. V. Gubin, V. Vlasenko, E. V. Rashkova, I. M. Malleev, A. V. Ivanov, S. Gerasyuta, G. Bulguryan, YaO Osipenko, O. V. Denisenko, D. A. Saakyan, M. H. Ivanova
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引用次数: 0

摘要

尽管直接口服抗凝剂(DOAC)的有效性和相对安全性已得到证实,但根据患者的遗传特征,降低与使用抗凝剂相关的并发症风险的问题仍然存在争议。应该制定一种个性化的方法来选择DOAC。在这篇文章中,我们回顾了DOAC对各种高凝相关疾病患者开处方的可行性以及DOAC应用的药理学方面的现有信息。进一步研究的必要性得到了证实,同时更广泛地引入基因多态性的分子生物学分析的重要性也得到了证实,基因多态性的存在影响着这些药物的疗效和安全性。在工作过程中,对MedScape、PubMed和eLIBRARY数据库中的出版物进行了分析。
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Current Issues of the Use and Efficacy of Direct Oral Anticoagulants According their Pharmacogenetic Features
Despite the proven efficacy and relative safety of direct oral anticoagulants (DOAC), the issue of reducing the risk of complications associated with their use, depending on the genetic characteristics of patients, remains controversial. A personalized approach to the selection of DOAC should be developed. In this article, we review the available information on the feasibility of prescribing DOAC to patients with various diseases associated with hypercoagulation and on pharmacogenetic aspects of the DOAC application. The need for further research is substantiated, along with the importance of a wider introduction of the molecular-biological analysis of gene polymorphisms, whose presence affects the efficacy and safety of these drugs. In the course of the work, publications from the MedScape, PubMed, and eLIBRARY databases were analyzed.
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