胰腺癌:从分子生物学到管理

M. Qadir, Farihah Malik
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引用次数: 0

摘要

胰腺生长是一种致命的感染,因此最初的猜测是必要的。胰腺疾病导致许多病人死亡。为了我们的安全,我们需要采取一些预防措施。至于戒烟,这是PaC的主要驱动因素,手术,化疗,放疗等药物都没有那么有效。因此我们需要思考PaC的基因组学,哪些特性包含在肿瘤中。在PaC期间改变的质量是DPC4、p53、p16和CDKN2(细胞周期蛋白依赖性激酶抑制剂2A)。尽管对这些品质的理解,我们可以追踪真正的问题,这个问题可以被治愈。我们可以在很小的机会上治疗这种感染,因为我们知道生物标志物是治疗这种疾病的药物焦点。目前可用的生物标志物是mirna、ca19 -9和癌胚抗原(CEA),它们可以对肿瘤生长进行早期预测。发现了一些有助于疾病治疗的药物靶点。如果我们抑制这些抑制剂法尼基转移酶、EGFR酪氨酸激酶(表皮发育成分受体)、ERK1/2(细胞外信号调节激酶),肿瘤的发展就会减少。
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Pancreatic cancer: From Molecular Biology to Management
Pancreatic growth is a deadly infection because of which its initial guess is essential. Pancreatic disease causes the passing of numerous patients. We need to take some preventive measures for our security. As to stop smoking, which is the primary driver of PaC. The medications which are accessible as surgery, chemotherapy, radiotherapy are not that effective. Because of which we need to think about the genomics of PaC. Which qualities are included in tumor. Qualities which changed amid PaC are DPC4, p53, and p16 and CDKN2 (Cyclin-Dependent Kinase Inhibitor 2A). despite the fact that the comprehension about those qualities we can follow out the genuine issue and that issue can be cured. We can treat this infection on the off chance that we know about biomarkers which go about as a medication focus to treat the ailment. The accessible biomarkers now days are miRNAs, CA 19-9 and carcinoembryonic antigen (CEA) which give the early forecast of growth conceivable. A few medication targets are found that will assist in ailment treatment. On the off chance that we repress these inhibitor farnesyltransferase, EGFR tyrosine kinases (epidermal development component receptor) ,ERK1/2 (Extracellular Signal-Regulated Kinase) the development of tumor can be diminished.
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