炎症在肿瘤进展中的作用:靶向肿瘤相关巨噬细胞

M. Varney, Rakesh K. Singh
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引用次数: 2

摘要

目前的证据表明,炎症在肿瘤进展中起着越来越重要的作用。宿主对癌症的反应与感染或伤口有许多相似之处。因此,许多肿瘤起源于感染或慢性炎症就不足为奇了。肿瘤被描述为永不愈合的伤口。局部产生的细胞因子,包括趋化因子,不仅吸引循环免疫细胞,而且激活周围微环境中的基质细胞。特别令人感兴趣的是肿瘤相关巨噬细胞(TAM)。TAM浸润肿瘤已被证明与几种癌症的不良预后相关。最近的研究表明,TAM在肿瘤微环境的重塑中起着新的作用,以支持肿瘤的生长和转移,并支持将TAM的反应作为新的治疗方法的概念。在这篇综述中,我们将讨论我们目前对巨噬细胞和炎症在恶性疾病进展中的作用的理解,以及开发更好的治疗和预防恶性肿瘤的治疗方法的可能性。
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The Role of Inflammation in Tumor Progression: Targeting Tumor-Associated Macrophages
Current evidence suggests an increasing role for inflammation as a critical link to tumor progression. The host response to a cancer shares many parallels with an infection or a wound. Thus it is not surprising that many tumors arise from areas of infection or chronic inflammation. Tumors have been described as wounds that never heal. The local production of cytokines, including chemokines not only attracts circulating immune cells, but also activates stromal cells in the surrounding microenvironment. Of particular interest are tumor-associated macrophages (TAM). The infiltration of tumors with TAM has been shown to correlate with poor prognosis in several cancers. Recent studies suggest an emerging role for TAM in the remodeling of the tumor microenvironment to support growth and metastasis and support the concept of modifying TAM's responses as novel therapeutic approaches. In this review, we will discuss our current understanding of the role of macrophages, and inflammation in the progression to malignant disease and possibilities for development of better therapeutics for the treatment and perhaps prevention of malignancies.
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