老年胃肠道间质瘤

M. B. Polyanskiy, Sergey P. Dronov, I. N. Zvyagin, Aleksey S. Rukavishnikov
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摘要

背景:胃肠道间质瘤(gist)占胃肠道原发性恶性肿瘤的1% ~ 3%。胃肠道间质瘤的全球发病率在每年每100万人7-15例之间变化。在大约95%的病例中,发病率是散发的。尽管在治疗这种病理方面已经取得了一些成功,但胃肠道间质瘤的治疗问题是迫切的,特别是在老年人和老年患者中。本研究的目的:研究老年人群中胃肠道间质瘤发展的年龄相关特征。材料与方法:回顾性分析56例不同年龄组的胃肠道间质瘤临床病例,按WHO分类。结果:免疫组化结构最常见的变异为梭形细胞,占62.5%。绝大多数病例肿瘤局限于胃,占82.2%。老年患者肿瘤体积大于中青年患者。在年龄较大的患者中,疾病最常在II期被发现。在大多数情况下,检测到共病病理,最常见的是几种心血管系统疾病的组合。结论:老年组胃肠道间质瘤以梭形细胞结构多见,肿瘤多局限于胃内(77.4%),肿瘤多局限于小曲部。多数病例肿瘤直径可达10.0 cm。平均而言,该疾病在第二阶段被发现。共病病理发生率为87.3%。在2020-2021年期间,由于用于诊断新型冠状病毒感染的胸部CT扫描次数增加,该疾病的检测频率更高,肿瘤大小更小。©2022 AME出版公司。版权所有。
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Gastrointestinal stromal tumors in elderly patients
Background: Gastrointestinal stromal tumors (GISTs) account for 1 to 3% of all primary malignant tumors of the gastrointestinal tract. The global incidence of GISTs varies in the range of 7-15 cases per 1 million people per year. In about 95% of cases, the incidence is sporadic. Despite the fact that some success has been achieved in the treatment of this pathology, the problem of GISTs treatment is urgent, especially in elderly and senile patients in particular. The aim of the study: To study the age-related characteristics of GISTs development in patients of older age groups. Materials and methods: A retrospective analysis of 56 clinical cases of GISTs in patients of different age groups according to the WHO classification was carried out in the study. Results: The most common variant of the immunohistochemical structure was the spindle cell one 62.5%. In most cases, tumors were localized in the stomach 82.2%. Elderly patients had larger tumor sizes compared with young and middle-Aged patients. In patients of older age groups, the disease was most often detected at stage II. In most cases, a comorbid pathology was detected, most often a combination of several diseases of the cardiovascular system. Conclusion: In patients of older age groups, the spindle cell structure of the GISTs is most common, the tumor was most often localized in the stomach (77.4%), most often the tumor was localized along the lesser curvature. In most cases, the tumor was up to 10.0 cm in diameter. On average, the disease was detected at stage II. Comorbid pathology occurred in 87.3% of cases. In 2020-2021, the disease was detected more often, the of tumors sizes were smaller, due to an increase in the number of CT scans of the chest for the diagnosis of the new coronavirus infection. © 2022 AME Publishing Company. All rights reserved.
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