{"title":"利法布汀负载固体脂质纳米颗粒的体外疗效","authors":"Manisha Patel, G. Saraogi, Shailesh Sharma","doi":"10.46624/ajptr.2019.v9.i5.002","DOIUrl":null,"url":null,"abstract":"Please cite this article as: Patel M et al., Ex-Vivo Efficacy of Rifabutin Loaded Solid Lipid Nanoparticles . American Journal of PharmTech Research 2019. Ex-Vivo Efficacy of Rifabutin Loaded Solid Lipid Nanoparticles Manisha Patel , Gaurav K. Saraogi, Shailesh Sharma 1.NIMS Institute of Pharmacy, NIMS University , Sobha nagar New Delhi Highway, Jaipur303121 (Rajasthan) 2.NMIMS, School of Pharmacy and Technology Management, Shirpur Maharashtra India ABSTRACT Tuberculosis is a ubiquitous, highly contagious chronic granulamatous communicable bacterial infectious disease caused by Mycobacterium tuberculosis and other species of same genera. “Rifabutin” which is useful in the management of tuberculosis. Formulated Rifabutin in the form of solid lipid nanoparticle evaluated for their efficacy ex-vivo by checking for various interactions. Thus, physiological parameters like cellular uptake, MTT cytotoxicity assay and hemolytic toxicity of rifabutin loaded mannosylated solid lipid nanoparticles are determined and compared. The present work establishes the suitability of rifabutin loaded mannosylated solid lipid nanoparticles as a delivery system.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":"35 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ex-Vivo Efficacy of Rifabutin Loaded Solid Lipid Nanoparticles\",\"authors\":\"Manisha Patel, G. Saraogi, Shailesh Sharma\",\"doi\":\"10.46624/ajptr.2019.v9.i5.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Please cite this article as: Patel M et al., Ex-Vivo Efficacy of Rifabutin Loaded Solid Lipid Nanoparticles . American Journal of PharmTech Research 2019. Ex-Vivo Efficacy of Rifabutin Loaded Solid Lipid Nanoparticles Manisha Patel , Gaurav K. Saraogi, Shailesh Sharma 1.NIMS Institute of Pharmacy, NIMS University , Sobha nagar New Delhi Highway, Jaipur303121 (Rajasthan) 2.NMIMS, School of Pharmacy and Technology Management, Shirpur Maharashtra India ABSTRACT Tuberculosis is a ubiquitous, highly contagious chronic granulamatous communicable bacterial infectious disease caused by Mycobacterium tuberculosis and other species of same genera. “Rifabutin” which is useful in the management of tuberculosis. Formulated Rifabutin in the form of solid lipid nanoparticle evaluated for their efficacy ex-vivo by checking for various interactions. Thus, physiological parameters like cellular uptake, MTT cytotoxicity assay and hemolytic toxicity of rifabutin loaded mannosylated solid lipid nanoparticles are determined and compared. The present work establishes the suitability of rifabutin loaded mannosylated solid lipid nanoparticles as a delivery system.\",\"PeriodicalId\":7701,\"journal\":{\"name\":\"American Journal of PharmTech Research\",\"volume\":\"35 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of PharmTech Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46624/ajptr.2019.v9.i5.002\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of PharmTech Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46624/ajptr.2019.v9.i5.002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Ex-Vivo Efficacy of Rifabutin Loaded Solid Lipid Nanoparticles
Please cite this article as: Patel M et al., Ex-Vivo Efficacy of Rifabutin Loaded Solid Lipid Nanoparticles . American Journal of PharmTech Research 2019. Ex-Vivo Efficacy of Rifabutin Loaded Solid Lipid Nanoparticles Manisha Patel , Gaurav K. Saraogi, Shailesh Sharma 1.NIMS Institute of Pharmacy, NIMS University , Sobha nagar New Delhi Highway, Jaipur303121 (Rajasthan) 2.NMIMS, School of Pharmacy and Technology Management, Shirpur Maharashtra India ABSTRACT Tuberculosis is a ubiquitous, highly contagious chronic granulamatous communicable bacterial infectious disease caused by Mycobacterium tuberculosis and other species of same genera. “Rifabutin” which is useful in the management of tuberculosis. Formulated Rifabutin in the form of solid lipid nanoparticle evaluated for their efficacy ex-vivo by checking for various interactions. Thus, physiological parameters like cellular uptake, MTT cytotoxicity assay and hemolytic toxicity of rifabutin loaded mannosylated solid lipid nanoparticles are determined and compared. The present work establishes the suitability of rifabutin loaded mannosylated solid lipid nanoparticles as a delivery system.
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